DMG stands for dimethylglycine, also called vitamin B15. It is found in low levels in foods, including meats, seeds, and grains. Both the human and animal body makes DMG from choline and betaine. It is suggested that increased dietary intake of DMG is to provide carbon to cells. It is also a precursor of SAMe. DMG appears to enhance oxygen usage, prevent the accumulation of lactic acid, improve muscle metabolism, function as an anti-stress nutrient to improve the cardiovascular system, and reduce recovery time after vigorous physical activity.

Therapeutic Uses of DMG
It has been recommended for use in pets with a variety of conditions including osteoarthritis at a dose of 50 to 500 mg per day. Its mechanism in the treatment of osteoarthritis is via an anti-inflammatory effect. Many doctors prescribe it for horses, dogs, and cats to improve performance and enhance recovery from various health problems. DMG is considered an anti-stress nutrient.

Holistic veterinarians have also recommended DMG as a supplement for pets with seizures and allergies. Research suggests that DMG may in fact be beneficial for these conditions, although the actual benefit for these conditions is unproven through controlled studies.

Studies have shown DMG can improve the immune response by potentiating both cell-mediated and humoral (antibody) immunity. Some holistic doctors also recommend DMG for pets with immune disorders such as cancer, feline leukemia virus infection, feline immunodeficiency virus infection and diabetes (at a dosage of 0.5 to 1.0 mg per pound daily). DMG is included in formulas for pets with heart disease. It is proposed to work by improving oxygen uptake and utilization.

DMG is also recommended as a natural therapy for pets with epilepsy at a dosage of 50 –500 mg per pet per day.

Safety Issues
DMG is extremely safe. The body converts it into its metabolites that are either used or excreted from the body.


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Shawn Messonnier, DVM

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Shawn Messonnier DVM Past Supporting Member, Oncology Association of Naturopathic Physicians Author, the award-winning The Natural Health Bible for Dogs & Cats, The Natural Vet’s Guide to Preventing and Treating Cancer in Dogs, and Breast Choices for the Best Chances: Your Breasts, Your Life, and How YOU Can Win The Battle!

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