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Dear Pharmacist,

I have two small nodules in my palm, they are small and painless, but I see (and feel) them below my pinky and ring finger. My doctor's appointment isn't for two months and I'm worried. Can you weigh in?

--C.S., Sacramento, California

Answer:I'm glad you have an upcoming appointment with a doctor who can examine your hand for other signs like dimples, pitted marks or bent fingers. Those little nodules could be related to so many things including Dupuytren's contracture which stands out in my mind. It starts out with tiny lumps in your palm as you describe. But again, a skilled physician can discern Dupuytren's from other conditions like trigger finger, stenosing tenosynovitis, a ganglion cyst, soft tissue mass, rheumatoid, sarcoma or something else. I won't pretend to know what you have, but for the sake of writing this column, I'll focus on Dupuytren's contracture because it's interesting and I've not covered it before.

Former president Ronald Reagan, Samuel Beckett and Margaret Thatcher are a few notable sufferers. These "lumps"in the palm suddenly appear, then other symptoms gradually appear. Ultimately, there is a tightening of the tissue in the hand, causing the finger(s) to curl down.

How much time between the appearance of lumps and the actual contracture? It varies, it's usually months to years. The contracture could be mild, or severe. No one is sure why it happens, but people with diabetes have a higher risk, as do middle-aged men. Other risk factors include your genetics, liver cirrhosis, epilepsy and those who have excessive oxidative stress. Oxidative stress occurs from free radical damage, like if you smoke, drink, have high insulin, high blood sugar, receive excessive medical ozone or UV blood irradiation, etc.). While researching this, I couldn't find many people claiming success with surgery. Unfortunately, treating Dupuytren's contracture doesn't get much attention or funding for studies so I'm happy to share what I know.

With Dupuytren's, your body produces too much of a cytokine called TGF? (transforming growth factor beta) and this contributes to fibrogenesis or thickening of the tissue. Reducing TGF? helps slow the disorder. In 2002, the breast cancer drug Tamoxifen was shown to help Dupuytren's by reducing TGF?. Then in 2009 an article appeared in Medical Hypothesis entitled, "NAC and ACE inhibitors can prevent the recurrence of Dupuytren's disease." The researchers slowed fibrogenesis with the dietary supplement called NAC (N-acetylcysteine) or ACE inhibitor drugs (ie lisinopril, enalapril). I think stretching, heat, acupuncture and red light (laser) could help in the early stages.

I also learned of a folk remedy, mix together: 5 ml (equal to 1 teaspoon) of topical Magnesium Oil with 20 to 30 iodine drops and 10 drops DMSO (usually sold online). Store this liquid mixture in an amber bottle. Apply a little bit with a cotton ball to your palm twice daily. Within weeks to months, this may improve contracture. Consult your physician before trying anything.

Suzy Cohen

Suzy Cohen, is known as America’s Pharmacist. She has been a licensed pharmacist for 24 years and is a Functional Medicine practitioner. She’s the author of 6 books, including her most recent Amazon #1 best-seller, “Thyroid Healthy: Lose Weight, Look Beautiful and Live the Life You Imagine.”

She was the host of The Thyroid Summit which broadcast worldwide in June 2014. Suzy has been a syndicated columnist for 19 years reaching 20 million in circulation each week. She is a Huffington Post writer, and also hosts her own syndicated medical minute on TV. Suzy has been featured on The Dr OZ Show 6 times, and has appeared on The View, Good Morning America Health, The Doctors and hundreds of other networks. She is a member of The Institute of Functional Medicine, also the American Academy of Anti-Aging Medicine, The American Pharmacists Association and ILADS, the International Lyme and Associated Diseases Society. You can read free articles and receive your free newsletter by visiting her website,

Books authored by Suzy Cohen include:

  • Thyroid Healthy
  • Headache Free
  • Drug Muggers
  • Diabetes Without Drugs
  • The 24-Hour Pharmacist
  • Eczema: Itchin’ for a Cure (kindle only)
  • Understanding Pancreatitis & Pancreatic Cancer (kindle only)