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hyaluronic acid

  • As French fashion designer Coco Chanel once said, “Nature gives you the face you have at 20; it is up to you to merit the face you have at 50.”

    We are all in search of a more youthful appearance. With age, comes the inevitable changes to our skin i.e., texture change, wrinkle formation, color change, etc. Our 21st-century world poses many challenges to maintaining glowing, radiant skin. Sugar-laden and processed foods, dehydration, air pollution, EMF exposure, alcohol, tobacco, sun damage, stress, and lack of sleep are all the thieves that will steal our youthful appearance.

    While, we cannot hold back time, modern science has given us some amazing solutions that allow us to seriously slow the aging process way down…and even roll it back a bit!

    Thankfully for us, there is good news on the skin rejuvenation front. By adding healthy lifestyle and dietary choices into the mix along with an effective skin care regimen, we can, indeed, merit a more youthful and healthy appearance.

    The Two Aging Villains: Inflammation and Dehydration
    Only 10 –15 percent of visible aging is directly related to genetics. That leaves the vast percentage of the aging process as the result of external conditions in addition to our personal choices and habits.

    If it’s not really about our genes, then what does initiate the aging process? It is now understood that the inflammatory process is one of the key aging villains. Research shows chronic inflammation undermines healthy, youthful skin.

    But, first, here is a quick definition of inflammation. Inflammation is an immune response that occurs when tissue has been injured or abnormally stimulated. Although it is a normal immune response, it is a problem when there is a continuous barrage of factors that keep the inflammatory process constantly active. An inflammatory response triggers the production of free radicals, which in turn starts a destructive chain of events, called the inflammation cascade. Immediate effects of inflammation on the skin can cause roughness, tightness, and spots (post-inflammatory hyperpigmentation).

    The process of continuous low-intensity inflammation, while invisible, damages our skin and will slowly lead to the inevitable signs of aging. It can accelerate fine lines, wrinkles and enlarged pores, as well as puffiness, sagging, blotchiness or reddening of the skin. Conditions such as eczema, psoriasis, and rosacea are also inflammatory symptoms. While aging, itself, initiates an inflammatory response, exposure to toxic chemicals, sunburns, stress, and denatured foods all add fuel to the fire of inflammation.

    SiverBiotics Anti-Aging Facial Serum

    On the record, many skin and personal care products contain many of the 10,500 toxic chemical ingredients that have been known to cause inflammation, free radical damage and aging to the skin.1 Becoming an educated consumer and choosing only the purest products is vital in the unregulated, Wild West world of skincare.

    The other major aging villain is dehydration. One of the main characteristics of youthful skin is its ability to naturally retain cellular hydration. As we age, the ability to hold moisture steadily declines.

    Cellular dehydration is exacerbated by lack of adequate water intake, chronic stress and aging. The most common indications of dehydration include dryness, flakiness, roughness, irritation, and cracking. These symptoms all add up to the look of prematurely aged skin.

    There is an important piece of the hydration story called hyaluronic acid (HA). It is a naturally occurring molecule found in cells throughout our body. However, the greatest concentration of HA is found in skin tissue. Almost 50 percent of the body’s HA is found here. HA occurs in both the deep underlying dermal areas as well as the visible epidermal top layers. Youthful skin is smooth and elastic from the abundant amounts of HA plumping up our skin cells.

    As we age, the amount of hyaluronic acid produced by our skin cells begins to decline and cell turnover can become sluggish—this is when those dreaded lines, wrinkles and rough texture tend to make their debut.

    So, what is the best solution to combat the two villains of skin aging: inflammation and diminishing levels of hyaluronic acid?

    The Two Pieces of the Skin Rejuvenation Puzzle
    In order to stop the destructive process of inflammation, a powerful, yet safe, anti-inflammatory solution is needed. Enter, a patented silver molecule called SilverSol®, one of the most effective solutions to safely repair as well as protect the skin from the damaging effects of inflammation. Through a new manufacturing technology, patented under multiple patents, this advanced Nano-silver solution, is the new generation of colloidal silver. It is recognized as the standard by which all other silver products are now measured.

    The patented SilverSol® technology from American Biotech Labs is a unique and highly effective form of silver. Throughout the ages and in cultures around the world, silver has been renowned for its anti-microbial effects. Even the famous Greek healer Hippocrates praised silver for its tissue repair and wound healing abilities. Thanks to advanced 21st-century technology, SilverBiotics by American Biotech Labs, is the most powerful as well as the safest safe form of silver ever created.

    Why is SilverSol® so important for youthful skin? Clinical studies proved that SilverSol® successfully killed all known forms of bacteria, even MRSA, within minutes.2,3 The same impressive results were achieved with viruses, yeast, and mold.

    But SilverSol® has other important skin benefits besides preventing and healing infections. In addition, it accelerates wound healing, calms inflammation, reduces scarring and promotes stem cell release and activation.4

    Also, because SilverSol® is so effective against the growth of pathogens, it takes on another important role in skin care products. It is an effective and safe preservative to maintain the purity of a skincare formula.5

    The addition of the patented SilverSol® technology in an anti-aging facial serum ensures ultimate protection and healing for your face. It offers a unique barrier against microbial infections as well as environmental assaults. At the same time, it gently promotes natural healing of the skin i.e., reducing all signs of inflammation, redness, blemishes and the appearance of scars. The second important piece of the rejuvenation puzzle is Hyaluronic Acid (HA) serum for plumping up dehydrated cells.

    As we age, the cells ability to hold moisture drops significantly. That translates into a loss of elasticity and glowing complexion. HA is phenomenal at penetrating the skin's upper layers where it affects tissue repair and protection while boosting elasticity and hydration. Another important feature of HA is its ability to transport nutrients from the blood directly to skin cells. HA has one more important feature, it protects the skin from the free radical damage caused by the sun's UV rays.6,7,8

    Hyaluronic Acid is a real superstar when it comes to rejuvenation. Because it has the unique ability to attract and retain more than 1000 times its weight in water, researchers have seen a significant increase in skin smoothness and wrinkle reduction.

    Hyaluronic Acid is essential for youthful skin because it:

    • Curbs premature wrinkling
    • Keeps collagen synthesis up
    • Increases skin hydration
    • Locks in moisture
    • Boosts skin elasticity
    • Enhances collagen production
    • Nourishes skin cell growth
    • Promotes firm skin tone
    • Antioxidant protection

    The New SilverBiotics Anti-Aging Facial Serum for Re-Vitalizing Aging Skin

    A truly effective skin rejuvenating product needs to protect against the two most age ravaging villains, inflammation, and dehydration.

    In the search for a truly effective anti-aging solution, American Biotech Labs formulated the ultimate in skin rejuvenation, called the SilverBiotics Anti-Aging Facial Serum. They combined their patented SilverSol® technology with a super powerful hyaluronic acid combination incorporating two different molecular weights.

    This special combination of the two molecular weights ensures that HA is able to reach the deepest layers of the skin while providing hours of intense cellular hydration and softness. The result is a truly rejuvenated you - diminished wrinkles and fine lines, well-hydrated skin, greater skin firmness and reduced skin discoloration.

    In addition to a daily regimen, always use the Anti-Aging Facial Serum after any skincare treatment such as laser procedures, chemical peels, waxing, micro needling, or plucking procedures to ensure rapid skin repair and healing.

    One of the truly unique features of SilverSol® technology is its proven ability to stimulate stem cell activation. That translates into faster healing and regeneration for more youthful skin.

    When choosing a good skincare product, be sure to look for one that contains all natural, non-toxic ingredients. That's why SilverBiotics Anti-Aging Facial Serum is your best choice. It is formulated without parabens, biphenyl A, phthalates, sulfates, alcohol, harsh preservatives or synthetic colors, which are commonly found in so many other skincare products.

    The SilverBiotics Anti-Aging Facial Serum is 100 percent pure. It is formulated with only SilverSol® liquid, Hyaluronic Acid, and Organic Vegetable Glycerin.

    How to Get the Best Results
    For achieving the best results, it is recommended to apply SilverBiotics Anti-Aging Facial Serum twice a day - morning and night. It rapidly absorbs into the skin with a light texture for deep penetrating hydration. It is so gentle that it is safe for all skin types, even the most sensitive skin.

    Why Are Women Raving about SilverBiotics Anti-Aging Facial Serum?
    This serum is truly remarkable in its ability to deliver on its promises. The many women who have been using this product have been thrilled with the results. Here are two real-life testimonials.

    Denise Willoughby from Langley, BC, Canada shares her experience.
    "For the past 15 years my husband Dr. Andrew Willoughby has been utilizing the American Biotech Labs' SilverSol® products to achieve remarkable wound healing results on his dental patients, so I am intimately familiar with these products given that I am one of those patients who has benefited.

    Recently I was asked to evaluate the new Anti-Aging Facial Serum. Compared to other HA products I have tried this product is superior. By using it morning and night on my face I was able to noticeably plump my skin and remove fine lines.

    This super hydrating new Anti-Aging Facial Serum has made my skin noticeably more supple and healthy looking. I would highly recommend this product to any person as part of their daily skin care regimen - it's a fantastic product. I hope I can keep evaluating it for years to come!"

    Although Rachel Armel, RN, has only been using the Anti-Aging Facial Serum for a short time, she sent in this testimonial.

    "I've only been using the facial serum for about a week and could not be more pleased with the results. I noticed my skin became so much better moisturized and the lines and wrinkles so much less noticeable. I never expected to see results this quickly so I can only imagine how I will look in a few months!

    I have tried so many anti-wrinkle/anti-aging products in the last few years and have found them disappointing and over-hyped but this product truly delivers. It's the real deal. LOVE IT!"

    An Invitation to More Radiant, Youthful Skin

    Turning back the aging process is no longer just wishful thinking. A more youthful appearance is possible for all of us. Nourishing our skin with an organic diet, adequate water intake, plenty of rejuvenating sleep, regular exercise and daily de-stressing strategies are the foundation for healthy skin. And thanks to the innovative SilverBiotics Anti-Aging Facial Serum, it is now possible to heal, repair, rehydrate, and regenerate the skin at the deepest levels at any age.

    No matter what your age, Coco Chanel would be happy to know that with SilverBiotics Anti-Aging Facial Serum we can all merit beautiful, radiant skin.

    References:

    1. Why this matters–Cosmetics and your health https://www.ewg.org/skindeep/2011/04/12/why-this-matters/
    2. Ultradilute Ag-aquasols with extraordinary bactericidal properties: role of the system Ag–O–H2O, Material Research Innovations, 2007 Vol 11 No 1.
    3. Silver Sol and the Successful Treatment of Hospital Acquired MRSA in Human Subjects with Serious Ongoing Infection. Pedersen, Gordon. (Published in A4M Anti-Aging Therapeutics Vol. 11.)
    4. Silver Sol Improves Wound Healing: Case Studies in the Use of Silver Sol in Closing Wounds (Including MRSA), Preventing Infection, Inflammation and Activating Stem Cells, Gordon Pedersen Ph.D. and Keith Moeller http://www.muvezi.org/Pedersen-Silver-Sol-Wound-Healing-MRSA.pdf.
    5. A Unique Silver Sol with broad antimicrobial properties. Antimicrobial, Vol, 3, No 11, April 2011 https://www.scribd.com/document/68258370/A-Unique-Silver-Sol-with-Broad-Antimicrobial-Properties
    6. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol 2012 Jul 1;4(3): 253–58.
    7. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effect. Int J Biol Macromol. 2018 Dec; 120(Pt B):1682–95. doi: 10.1016/j ijbiomac.2018.09.188. Epub 2018 Oct 1. https://www.ewg.org/skindeep/2011/04/12/why-this-matters/
    8. Anti-aging and filling efficacy of six types of hyaluronic acid based dermo cosmetic treatment: double blind, randomized clinical trial of efficacy and safety J Cosmet Dermatol 2014 Dec; 13(4): 277–87.
  • In the past couple of years, oral forms of hyaluronic acid have become available. Oral HA is a nonprescription product that’s sold as a dietary supplement. The benefits of an oral formulation compared to injections are obvious: lower cost, no pain, lower risk, and improved convenience. The positive results for patients have vaulted this product into the limelight.


    The number one cause of disability in America isn’t heart disease or diabetes—it’s arthritis. According to statistics from the federal Centers for Disease Control (CDC), one in three adults is now affected by an arthritis-related condition.

    Arthritis is a general term for a group of conditions that cause pain, stiffness, and swelling in the joints. The most common form of arthritis is osteoarthritis, sometimes called “wear and tear” arthritis. Most people with arthritis have osteoarthritis— in fact, some 21 million American adults suffer from it.

    People with arthritis often face serious reductions in their quality of life. The pain, stiffness, and inflammation make it hard to stay active, but inactivity can lead to a downward spiral of worsening health. When activity levels drop, depression, obesity, diabetes, heart disease, and problems with work and relationships often develop. And inactivity actually makes sore joints even worse, which just accelerates the downward spiral. For most people, life just isn’t as enjoyable with arthritis.

    New Treatment Options
    The good news is the high prevalence of arthritis has led to increased awareness and increased research efforts. The most exciting part about the new treatment options that are now becoming available is they don’t just relieve pain. They actually improve function while also being very safe. Unlike anti-inflammatories such as naproxen (Aleve), for example, treatments such as glucosamine and hyaluronic acid don’t cause gastric bleeding or ulcers, and they don’t raise your risk of a heart attack, stroke, or kidney disease.

    In the 1990s, hyaluronic acid (HA) became available as a treatment for knee osteoarthritis. For people with severe knee arthritis, injecting HA into the joint often provides relief. Injectable HA is a prescription product that has to be administered by a physician. Most patients need a series of three to five weekly injections. Injectable hyaluronic acid is well-established as a safe therapy for osteoarthritis. In fact, it’s part of the American College of Rheumatology guidelines for treating osteoarthritis of the knee. Injectable HA works reasonably well. After receiving the series of injections, over half of all patients have improvements in pain and function that can last for up to a year. Because injectable HA provides long-lasting relief, osteoarthritis patients can often avoid the dangers associated with over-the-counter or prescription anti-inflammatory drugs.

    Injectable HA has some significant drawbacks, however. Receiving an injection directly into the joint isn’t something to take lightly. It’s an invasive procedure that involves pain and a small chance of introducing an infection in the joint. It’s expensive—the series of injections can run to $1,500 and may not be covered by health insurance. It’s also inconvenient to keep going to the doctor for several weeks in a row to receive the full series of injection—or repeat injections, if necessary.

    In the past couple of years, oral forms of hyaluronic acid have become available. Oral HA is a nonprescription product that’s sold as a dietary supplement. The benefits of an oral formulation compared to injections are obvious: lower cost, no pain, lower risk, and improved convenience. The positive results for patients have vaulted this product into the limelight.

    Understanding HA
    To appreciate what a breakthrough oral HA is, it helps to understand the crucial role of HA in joint health. In your body, HA is a naturally occurring family of extremely large molecules that are contained in many tissues, not just the joints. HA is one of the components that give our tissues flexibility. Your eyeballs, for instance, are “squishy” mainly because of their high HA content. The same goes for the cartilage in your joints.

    Joint cartilage (what doctors call articular cartilage) is a glistening, smooth, translucent, whitish-colored living tissue found on the ends of your bones. Joint cartilage caps the ends of the bones in the 230 different joints found in the human body. When it’s healthy, cartilage is extremely smooth. It provides a low-friction environment for easy movement and also acts as a shock absorber to protect your bones and keep them from fracturing with activity.

    Hyaluronic acid is essential for healthy cartilage. It’s the chemical backbone that holds together the molecules, such as chondroitin sulfate, that make up the cartilage and give joint cartilage its special properties. HA is what makes joint cartilage the smoothest and most friction-free substance in nature. Nothing man-made can approach the performance of this remarkable tissue.

    In any joint, the whole structure of bone, cartilage, ligaments, and tendons is surrounded, held together, and protected by a watertight, fibrous joint capsule. Specialized cells called synoviocytes line the interior portion of the joint capsule. They produce the synovial fluid—a thick, clear substance that looks and feels like raw egg white. Synovial fluid fills the space within the joint. It lubricates the articular cartilage, much as grease lubricates the ball joints of your car. Synovial fluid also increases the effectiveness of shock absorption in the joint, much as hydraulic shock absorbers smooth out the ride of your car. Because joints don’t have a blood supply of their own, the synovial fluid also carries nutrients into the joint and carries waste products out.

    Osteoarthritis and HA
    Where does HA fit into joint health? It’s the principal functional component of synovial fluid. HA is what makes synovial fluid thick and viscous—and it’s these properties that are vital to normal joint function. But when osteoarthritis strikes, the hyaluronic acid in the joint is affected. Here’s how it happens: The joint cartilage on the ends of the bones slowly erodes, the bone underlying the cartilage changes (leading to bone spurs and pain), and the synovial fluid in the joint changes in character. Specifically, the amount of HA in the joint drops. In severe osteoarthritis, the level of hyaluronic acid in the joint fluid may decrease by 75 percent or more. Because HA serves as a shock absorber and lubricator, it’s no wonder that a big decrease in such an important molecule results in adverse consequences. When HA levels in the knee drop, for instance, the result is a creaking or grinding sensation, pain, and often a condition called “movie-goers knee.” It may sound funny, but movie-goers knee is no joke. It’s a real medical condition that occurs after someone with knee osteoarthritis sits with the knee bent at a sharp angle for a prolonged period of time—such as sitting through a feature movie or driving a car for a couple of hours. Upon arising, a sudden, sharp, stabbing pain occurs in the knee. The pain usually goes away after walking a few steps, as the remaining fluid in the knee coats the surfaces of the cartilage and cuts down on the friction.

    The prevailing theory of how HA works is that the molecules attach to binding sites on cells within the joints. Once the attachment is made, it triggers a complex cascade of events within the cells. One of the things that seems to happen is the HA molecules inhibit some of the enzymes that help break down the cartilage matrix in the joint. HA also seems to inhibit some of the natural chemicals, such as interleukin-1b and prostaglandin E2, that create inflammation in an arthritic joint. The anti-inflammatory mechanism of HA isn’t fully understood, but we do know it’s quite different from that of anti-inflammatory drugs. HA molecules also appear to disrupt some of the nerve impulses that transmit pain signals from the joint to the brain. Importantly, HA molecules can stimulate the cells that line the joint capsule and trigger them to manufacture even more hyaluronic acid—something highly desirable in osteoarthritic joints.

    When there’s not enough HA in a joint, all the things it does to maintain pain-free normal function don’t happen as well— that’s where supplemental HA comes in.

    Choosing the Best HA Supplement
    As researchers learn more about the HA pathways in the joints, they continue to discover new ways in which HA helps relieve pain and improve function in patients with osteoarthritis. One of the things they’ve learned is oral HA supplements can be very effective—but only if they’re a high-quality product that closely mimics the body’s own HA.

    Today the oral forms of hyaluronic acid sold as dietary supplements come from three general categories: low-purity animal extractions mixed with large quantities of (relatively inactive) collagen; fermentation from bacteria; or concentrated extraction from avian cartilage. The original pharmaceutical forms of injected hyaluronic acid were all derived from the avian cartilage, so it makes sense this is also the optimal form for dietary supplements. Low-purity animal extractions mixed with collagen are undesirable because of two reasons. To get an adequate quantity of hyaluronic acid from these supplements, you’d have to take them in very large amounts. Also, it’s questionable whether the biologic activity of this source of hyaluronic acid compares with the others.

    Hyaluronic acid derived from bacterial fermentation may also be less functional and it doesn’t have some of the natural active components found in the concentrated extractions from avian cartilage. Perhaps this helps explain the results of an internal study comparing the effectiveness of fermented HA to a concentrated extract from avian cartilage. When a culture of living synovial cells was exposed to the avian extract, the cells were stimulated to produce twice as much HA as when they were exposed to the bacterial HA—even though the concentrations of each product was the same (200 mcg/ml ).

    It’s also important to note that concentrated avian extracts have been used in most of the important worldwide research that has been done on HA. The concentrated extractions have been utilized extensively in the clinic and in large human studies (some of long duration) sponsored by the pharmaceutical industry.

    Hyal-Joint® Oral Hyaluronic Acid Supplements
    Hyal-Joint oral hyaluronic acid supplements appear to be the best available product. This product is a concentrated HA extraction from avian cartilage and also contains other naturally active components such as vital glycosaminoglycans. Hyal-Joint has been studied in a number of laboratory experiments, animal studies, and in a human clinical study. Even more research is underway. The studies suggest that Hyal-Joint raises HA levels in the joints and, just as important, also stimulates the body to produce more of its own natural HA. In the first human study, the participants took only 80 mg of Hyal-Joint a day, an amount that fits into a small capsule or tablet. This daily dosage delivers approximately 48 to 54 mg HA, 4 to 12 mg other glycosaminoglycans, and 16 to 24 mg collagen. A clinical trial is underway now using a smaller dose of just 40 mg, and some supplement manufacturers are considering adding 20 mg of Hyal-Joint to existing joint health formulations containing other active components such as glucosamine and chondroitin sulfate.