In this article, I discuss the aging process in general for men, look at testosterone and hormonal changes, and then focus on maintaining prostate health and sexual function over the later years. And clearly for men, their prostate and sexual function are important to feeling youthful. Those that remain lovingly active, sexually and sensually, often feel better in many other ways as well.

Let me first say a few words about male aging, which I hope to experience, only very slowly with vitality and verve. We each have our genetics and biological clocks. Hopefully, if we play our cards right with healthy habits, understanding our risks and disease potentials, we can outlive our parents and ancestors. And for most issues of genetics and aging, lifestyle can trump our genetics and give us greater health and less disease.

Men need to look at and take action to prevent some of the common diseases that take us out of life too early. The big ones here are the cardiovascular diseases that start with inflammation, rising blood pressure, higher cholesterol, and subsequent atherosclerosis. The other is weight gain with rising blood sugar and insulin resistance of pre and early diabetes that speeds up cardiovascular problems. Lifestyle is so important to all of these common aging issues and helps in preventing, or at least delaying them. The lifestyle keys are focused on diet, exercise, and stress management.

Cancer risk is also a health and longevity threat, and here the colon and prostate are major concerns. These areas can and should be checked with some regularly to pick up any early changes. Colonoscopy, digital rectal exams, and PSA blood tests in men are well accepted for early diagnoses of these common cancers, although PSA tests have more recent controversy (as does mammography in women) because of potential fear and over-treatment that they can cause unnecessarily; also, there is controversy on how many of prostate cancers should be left alone and watched rather than suggesting and using aggressive treatments of surgery, chemotherapy, and radiation. Lung cancer is a minimal risk if you don’t or have not smoked. If so, regular chest x-rays are a test to consider.

It is important for men in the aging process to maintain normal weight, blood pressure, blood cholesterol, and blood sugar. Abdominal obesity from excess calories from refined foods, especially flour and sugars products, along with excess alcohol use can cause higher risks for many diseases. In current times, it’s easy to be overweight (or let’s say, harder to stay trim), however, research is showing that health and longevity can be protected with exercise and staying fit even with being somewhat overweight. A sedentary life with overeating and being overweight can create a high risk of disease and a shorter lifespan.

Tips for Healthy Aging

• Avoid Overeating and rich, fatty foods in your diet.
• Minimize Sugar, Flour, And The Many Refined Foods made from them as well as excessive alcohol.
• Maintain Normal Weight.
• Focus Your Diet around fresh vegetables with quality proteins and fresh fruit.
• Get Regular Exercise and avoid a sedentary lifestyle.
• Stretch to stay young and flexible.
• Stay Strong with weight training; muscle mass is important for healthy aging.
• Do Aerobic Exercise to stay fit and maintain endurance.
• Practice Stress Reduction such as meditation, breathing, qigong, tai chi, yoga, or relax out in nature.
• Listen To Your Body, and partner with your healthcare provider to address imbalances or symptoms such as sleep problems, digestive issues, sexual dysfunction, allergies, weight loss or weight gain, and stress issues; find ways that work to resolve these issues.
• Do Your Annual Physical Checkup to catch early signs of pending health problems.
• People Who Live A Long And Healthy Life tend to practice forgiveness, find a good balance between work and relaxation, feel gratitude and joy every day, nurture their creativity, stay connected with their friends and family, make a living doing something they enjoy, and use their talents and gifts to be of service to others. Wow! That’s another whole list.

HORMONAL CHANGES IN MEN

Many things change as we age, and this is true for blood levels of our hormones along with lower functions. For men, the many related hormones could become lower with time. This relates especially to testosterone, but also to thyroid and adrenal hormones, and less so to estrogen and progesterone. DHEA, or dehydoepiandrosterone, is a precursor substance that is produced form cholesterol molecules in the adrenals, and acts as a precursor for testosterone and estradiol. For both men and women, better levels of blood DHEA-S (sulfate) tends to be associated for both men and women with feeling better with a greater sense of well-being as they age.

In my office, I measure several blood levels when assessing men, especially over 40 years old. These include testosterone (often the total and “free” levels), DHEA-S, thyroid, and sometimes estradiol levels; if there’s fatigue I may order a 4-test saliva sample to check cortisol levels throughout the day. You and your doctor need to clarify the difference in test levels between the wide range of normal and more optimal levels.

If testosterone levels are low normal and there are symptoms accordingly, along with the person’s request to experience how they feel with some added body levels of circulating testosterone hormone, I will prescribe a topical hormone cream to apply daily for a couple months. Low male hormone levels can affect energy, mood, strength, sexual function, and vitality. After trying the treatment, we can evaluate the results and see what symptoms may have improved and how that correlates with blood or saliva levels of hormones. Testosterone can also be used as injection in oil, given every two-three weeks on a regular basis.

The use of testosterone replacement or enhancement in aging men is a controversial treatment. Over recent decades, it was thought to be cardio-protective as well as improve stamina and vitality; however, recent reports are suggesting that testosterone adversely affects the cardiovascular system. I don’t believe it as of yet, but it’s wise to review this aspect with your practitioner if you consider testosterone therapy.

PROSTATE PROBLEMS AND PREVENTIONS

It appears that the common disease among men over 50 (and now over 40) involves the prostate sex organ (and the colon, with stagnation and toxicity, diverticulitis and cancer). The Western lifestyle of stress and sitting plus often hours of driving and traffic, working, and TV watching; stuffing food and emotions; eating animal flesh and milk products; consuming sugary foods and caffeine; and using alcohol regularly—sets the stage for chronic, debilitating and degenerative diseases, such as cardiovascular problems, cancer, and arthritis, as well as prostate enlargement (BPH—Benign Prostatic Hypertrophy) and prostate cancer.

The prostate is a fibro-muscular organ, about the size of two walnuts placed together, and it sits at the bottom of the man’s pelvis behind the genitals and in front of the rectum. It can be felt (palpated) with the medical “digital exam” whereby a doctor sticks his gloved and lubricated index finger in through the anus and pushes forward. We should feel the pliable yet firm lobes without any enlargement, swelling, lumps or stony material. And the patient should not feel any pain, however, it could feel uncomfortable with a pressure like you have to urinate. Some symptoms of prostate enlargement or infection may be a pressure or swelling feeling in the perineum, or even more commonly, frequent urination and difficulty in starting or stopping urination. Men often need to get up two or three times at night to pee, which can lead to sleep issues as well. There may also be some change in the urine stream or force behind the urination. The ureter, or tube that passes from the kidneys and through the bladder, also goes through the prostate tissue and then through the penis. Thus, when the prostate is swollen, it may interfere with the urine flow.

A blood test can also be done to measure an antigen that is created by prostate cancer cells. It’s called the PSA (Prostate Specific Antigen) and if it’s elevated, that may mean prostate cancer is present. With inflammation or infection, the PSA can also go up; thus, it may need to be double-checked and/or rechecked after a course of antibiotics to treat any potential infection. If the elevation persists, even after any infection is treated, this may require further testing, as I believe it’s always wise to find out what is going on in our body. If it’s bad news, at least we can deal with it from there. Other tests to investigate the prostate further include a prostate ultrasound (sound wave assessment of the prostate tissue), a cat scan or the new body scan (both which utilize x-ray), and a prostate biopsy, which is usually done by an urologist. Luckily, many prostate cancers are slow growing or have not spread; yet they still can cause medical problems and metastasize over time.

The best overall plan, however, is to stay healthy and to maintain a healthy prostate.

As reviewed above, this involves staying young and in shape; maintaining sexual activity; getting regular exercise; managing your stress levels; taking stretch and activity breaks from long periods of sitting and computer work; eating a wholesome diet with lots of fresh veggies and quality proteins plus healthy fats; and avoiding excess substance use, especially of refined sugars, red meats and alcohol, while obtaining adequate essential fatty acids daily, such as two teaspoons of flaxseed oil, as well as adding fish oils and evening primrose oil. These are all ways that may help to prevent prostate problems.

Lycopene found in tomatoes (highest amount), watermelons, pink grapefruits, guava, and papaya is an antioxidant that mops up free radicals and helps protect the body against cancer. Cooked tomato products like tomato sauce allows lycopene to be more readily absorbed by the body. In research studies, two servings of tomato sauce a week are enough to lower the risk of developing prostate cancer.

Cruciferous vegetables such as broccoli, cauliflower, cabbage, Brussels sprouts, bok choy, collards, broccoli sprouts, Chinese broccoli, broccoli raab, kohlrabi, mustard greens, turnip, radish, rocket, watercress, and kale all contain sulforaphane, an anticancer and antimicrobial compound that helps the body repair damages caused by cancer cells while slowing down its growth. Another added benefit of eating these nutrient-rich cruciferous vegetables is the decreased risk for cardiovascular diseases while providing higher levels of vitamins and minerals that are also needed to prevent or fight cancer. The sprouts of these vegetable seeds, especially broccoli sprouts, have been shown to have anti-cancer effects.

Avoid charring meats when cooking (especially in grilling) to reduce the levels of a cancer-causing substance known as PhIP which has been associated to the development of prostate cancer in lab animals. Slow roasting, stewing, and broiling (without charring), are better ways to cook meats.

Zinc, selenium, Coenzyme Q10, vitamins C and E, vitamins K2 and D3, and the B vitamins, particularly B6, are all important for a healthy prostate, as are a number of herbs, which can also be used to treat prostate problems as well. There are two herbs that are specifically useful in preventing and treating prostate diseases, and thus, supporting sexual function. They are Serenoa repens and Pygeum africanum.

Saw palmetto berry (Serenoa repens) has been shown to effectively diminish pain, inflammation and enlargement of the prostate, as well as to reduce urinary urgency. It may work by inhibiting dihydro-testosterone (DHT), thereby reducing its stimulation for cell multiplication. Saw palmetto has been used for centuries and is also thought to have a mild aphrodisiac effect, as well as increasing sperm production and sexual vitality.

Another useful herb comes from an African evergreen tree, Pygeum (Pygeum africanum), and has been shown in research to reduce prostate enlargement and inflammation; it may also help stimulate libido. Pygeum has many natural chemicals that have anti-inflammatory and other positive effects on energy and bodily functions.

Some prostate formulas also may contain other herbs like nettle, or pumpkin seed extract or oil (higher in zinc and supportive of prostate health), and beta-sitosterol, a healthy fat that also supports prostate. Most men over 40-50 can benefit form the regular use of a good prostate health formula to both support this organ and prevent prostate problems.

The herbs and formulas work well and often at less expense and less potential harm or side effects than the popular drugs, such as Proscar or Flomax. These medications are typically prescribed by doctors for men with prostate enlargement or urinary symptoms.

Ultimately, it is conceivable that if we follow the aforementioned lifestyle advice, we can avoid treatment altogether and maintain both a healthy prostate and our sexual health and vigor. Long-term survival rate approaches 100 percent when prostate cancer is detected early. The ACS (American Cancer Society) recommends a PSA blood test and digital rectal examination be offered annually for men starting at age 50, although that is more recently questioned as to whether this test actually helps in saving or prolonging lives. Men in high risk groups, such as African American men, those with family histories of this disease, or with a history of rising PSA levels as well as altered levels of estrogen or testosterone, may begin testing at a younger age (i.e. 40-45 years). Men, who are not at high risk but are between 40 and 50 years old, may want to do both tests every two-three years.

It is far better to pick up any medical problems early, and this certainly applies to the prostate. Stay Healthy!

A good web site to keep abreast of prostate cancer research and treatments is www.ProstateCancerFoundation.org. Check out the latest research and guidelines.

The post Male Aging, Hormone Support, And Prostate Health appeared first on Total Health Magazine.

The prostate rings the urethra, the tube that transports ejaculate and drains urine from the bladder. As the prostate expands in size, the urethra may be squeezed and narrowed, causing urinary symptoms such as frequent urination (particularly during the night), urgency, difficulty starting the stream, a weaker stream, dribbling at the end, and incomplete emptying.

These are the symptoms of benign prostate hyperplasia (BPH), a condition that in mild, moderate or severe form afflicts four out of five men aged 40 and older. (It’s THE most common health problem among older men.) And as I mentioned earlier, many men with CFS/FMS have prostate irritation called prostadynia, with similar symptoms and sometimes pelvic pain. The prostadynia symptoms often improve with long-term antifungals, antibiotics in select cases, and the nutrient quercitin.

There are several medications that doctors often use to treat BPH. Flomax (a so-called alpha-blocker) works by relaxing the muscles where the bladder and urethra intersect, allowing for easier flow. Proscar and Avodart work by decreasing production of dihydrotestosterone (DHT), the compound that pumps up prostate cells. But like most medications, they have downsides. For one thing, they’re expensive. And they’re not without side effects, from decreased semen volume to painful orgasms (from Flomax).

Natural approaches to optimize the health of your prostate are often effective alternatives to prescription medications. In this article, I’ll discuss five herbals that can help keep your plumbing in tip-top shape.

Herbals That Can Help Optimize Your Prostate Health

1. Saw Palmetto Extract
Also known as Serenoa repens, saw palmetto blocks DHT effects and balances hormones. Give it six weeks to work. Over the years, there have been dozens of studies on saw palmetto involving thousands of men with varying results. Many have shown that the herb works to optimize prostate health. Other studies have produced negative results.

My bottom line is that I’ve found the herb effective in helping to promote healthy prostate function in older men. I also think it’s a lot safer than drugs, and research agrees that it’s very safe. In fact, in the most recent analysis (conducted by researchers at the University of California, San Francisco, and published in the Journal of Urology in April, 2013) doses of saw palmetto three times higher than typical, taken for 18 months, produced “no evidence of toxicity” of any kind. (Take 160 mg, 2x day).

Other herbs can also help prostate health by balancing inflammation and hormone function. These include:

2. Boswellia
Boswellia (Boswellia serrata), also known as frankincense, is one of my favorite herbs. It balances several key immune-modulating enzymes, which can leave your prostate feeling a lot less twitchy!

3. Nettle
Given its name, Nettle (Urtica dioica) might be the last plant you would think of using to settle down your prostate. But this is another must for anyone who wants to help their prostate through herbal approaches.

Nettle is rich in beta-sitosterol, a plant sterol that has hormone-balancing effects. So, like saw palmetto, it helps optimize prostate health. It does this by:

• Blocking the binding of sex hormone binding globulin (SHBG) to the prostate.
• Inhibiting aromatase, an enzyme that affects the body’s testosterone metabolism.
• Inhibiting adenosine deaminase (ADA) activity of prostate tissue.

Nettle is a very powerful ingredient and one that is key for an optimized prostate health formula. (Use a strong 10:1 extract.)

4. Beta-Sitosterol
Double-blind clinical studies have found that beta-sitosterol improves urinary flow in men, and that is big news for any man who feels like he must constantly go to the restroom, or who feels like his bladder doesn’t fully empty after each trip.

5. Sesamin
This comes from the sesame plant, and has been shown to block the activity of a protein complex called NF-KB, which promotes the growth of tumor cells.

All five of these herbals can be found in combination in a product called “Healthy Prostate” by EuroPharma.

Other Helpful Prostate Tips?

Add zinc and selenium.
Adding daily doses of these two minerals can help maintain prostate health (both should be present at these amounts in a good multivitamin)—and may boost the effectiveness of saw palmetto. In one study, German researchers measured blood selenium levels in 21 men with prostate problems and found their blood levels “significantly lower than the recommended normal range.” They recommend selenium supplementation to help optimize prostate health. (Take 15 mg zinc, 1x day. 50 mcg selenium, 1x day.)

Regular exercise: protection against prostate cancer.
Research shows that regular exercise can contribute to optimal health of the prostate gland, and may help lower the risk of developing prostate cancer. I recommend a 30-60 minute daily walk outdoors. Not only do you get a workout, you also get a nice dose of healthy vitamin D—a vitamin that in one recent study was associated with lower levels of prostate cancer (July 2012 issue of the Journal of Clinical Endocrinology and Metabolism).

The post Prostate Got You On The Run? appeared first on Total Health Magazine.

BPH is hardly the lone prostate and sex hormone related issue that can be troubling to men. Aside from prostate cancer, which for most men is so slow growing as to not be life threatening, many men are concerned about low testosterone, which has its own repercussions. Two of the repercussions of low testosterone are a low level of muscle-maintaining free testosterone and elevated levels of estrogen produced from testosterone by a pathway referred to as the aromatase pathway. Fortunately, there are a number of safe natural compounds that can help to regulate both sides of this equation.

Protective herbs and nutrients have counterparts that increase the risks of various conditions. Some of these potentially damaging compounds are prescriptions given for unrelated conditions and this provides a rationale for being cautious about prescription drugs. What you do not know definitely can hurt!

PROTECTIVE AND SUPPORTIVE NUTRIENTS AND HERBS

Omega-3s
In 2013, experts slammed a claimed fish oil/omega-3 fatty acid intake link to prostate cancer as “scaremongering.” The trial in question purported to find increased risks for total prostate cancer as well as increased risks of both low-grade and high-grade prostate cancer, an increase of 71 percent in this latter category.² The responses were quick and brutal. One nutritionist (Duffy MacKay, vice president of scientific and regulatory affairs at the for Responsible Nutrition (CRN)) pointed out, quite correctly, that the findings of this study were based on blood level differences so small that “[t]his change [of 0.2%] literally could have occurred if somebody ate a fish sandwich on their way to get their blood drawn.”³ Both the consumers of the low and the high levels of long chain omega-3 fatty acids were within the normal blood range.

Others pointed out that the findings of the study clearly imply that men in countries with high levels of consumption of seafood, such as Scandinavia and Japan, should exhibit high levels of prostate cancer, yet the opposite is the case. Alan Ruth, PhD, CEO of the Irish Health Trade Association observed, “[i]n a 2010 meta-analysis of 31 studies published in the American Journal of Clinical Nutrition, the risks of prostate cancer diagnosis calculated for high fish consumption ranged from a 61% decrease in risk to a 77% increase in risk, and several showed no significant differences in risk at all…In the same meta-analysis, pooled data from four studies on fish consumption and death from prostate cancer (rather than diagnosis of prostate cancer) found a 63% decrease in risk for high fish consumption.”⁴

Especially interesting in this dust-up is the recent attempt to rehabilitate omega-6 fatty acids. In pre-modern times, the intake of omega-3 to omega-6 fatty acids in the diet typically was in the range of one-to-two, whereas today in the United States it regularly may be as low as one-to-twenty-five, with prostate cancer rates climbing steadily over the last 60 years. In this instance, a headline is revealing: “Corn oil, omega-6 could speed up prostate cancer.”⁵ Journal article titles are more prosaic, yet just as damning: “A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer.”⁶

Barry Sears, who has written for years on the health effects of fatty acids, both good and bad, tartly comments in his blog, “Omega-3 fatty acids and prostate cancer? Oh, really?”⁷ Among other things, Sears demonstrates how easily a statistically significant blood reading of fatty acid profiles can be attached to otherwise clinically irrelevant findings. The take away message in this case is that the experience around the world repeatedly has been that prostate risks, especially death from prostate cancer, are lower in matched populations that consume more fish. There is nothing in recently published research that should make us doubt that improving the omega-3 to omega-6 ratio in our diets is a good goal at which to aim.

Grape Skin Extract & Resveratrol
In many areas in the US and the United Kingdom (Scotland has not yet opted out of the Union), one cannot visit a doctor without being queried about alcohol intake and then the required lecture on the evils of alcohol. The distinction as to the source of alcohol in the diet routinely drops out despite the fact that red wine has been recognized in Europe for centuries as exhibiting various health benefits and little downside as long as consumed in moderation. It turns out that red wine, often thought of in terms of the heart, may benefit the prostate, as well.

The trick to the studies is that the researchers must work vigorously to screen for the different sources of alcohol over the course of a man’s life. If this is done, then the research is likely to confirm that a glass of red wine per day may be protective against the risk of prostate cancer.⁸ Less clear is which compounds in red wine are protective. Perhaps many are. A recent study on grape skin extract and resveratrol identified several protective mechanisms of action.⁹ Some of the factors linked to resveratrol have been known for years, whereas other mechanisms and, similarly, the benefits of other red wine compounds, are being vigorously researched. Grape seed components (proanthocyanidins) are another example of a source of anti-cancer benefits.¹⁰ Given the huge volume of papers being published today on the health-protective benefits of red wine and its ingredients, it is a reasonable conclusion that most men may benefit from one or two glasses of red wine per day consumed with meals.

Quercetin & EGCG
The dietary bioflavonoid quercetin is well known to readers of this magazine, as is epigallocathechin gallate (EGCG). Both compounds are considered to be health protective and quercetin, in particular, is known to improve the uptake (bioavailability) and the benefits of many other compounds found in the diet and in herbs. Papers routinely show greater efficacy or even benefits where none initially were found, when quercetin is combined with resveratrol, with sulphorafane, with EGCG, etc. One of the more interesting recent findings is that these combinations sometimes not only can help to prevent the transformation of cells from precarcinogenic stages to active cancer, but also can interfere with or eliminate entirely cancer stem-cell characteristics. Cancer stem cells are the ultimate source of cancer self-renewal, so this action by the combination of quercetin and EGCG is a warm recommendation.¹¹

Bitter Melon
Bitter melon has received quite a bit of publicity recently with regard to pancreatic cancer. It would be unfortunate were the exploration to end there. Several researchers have reported that treatment of bitter-melon-related products in a number of cancer cell lines induces cell cycle arrest and apoptosis without affecting normal cell growth.¹² Researches targeted specifically at prostate cancer have demonstrated that the impact of bitter melon extends to this area.¹³ Admittedly, bitter melon is not a staple at the American table. Perhaps that should change. See my earlier article, “Going WILD with Bitter Melon for Blood Sugar Support.”¹⁴

Pomegranate
Pomegranate is a fruit long associated with healing and medicine. Indeed, the pomegranate is on the crest-of-arms of the British Royal Society of Medicine and of many other ancient organizations devoted to healing. A quick look at the PubMed database shows that the keywords “pomegranate” and “prostate” bring up 60 studies. Many of these studies have been promising, especially when pomegranate was added to other ingredients with related and differing mechanisms of action. For instance, in 2013 the polyphenol rich whole food supplement Pomi-T® (pomegranate seeds, green tea, broccoli, and turmeric) was reported to have a direct anti-cancer effect in men with prostate cancer.15 These results were confirmed in a larger clinical trial published in 2014.¹⁶

Thymoquinone and Black Seed
Few Americans have heard either of black seed or thymoquinone (TQ). The former is famous for healing in the areas in which it grows naturally, meaning much of the eastern Mediterranean through the Near and Middle East all the way to India. Mohammed is reputed to have said that the seed cures every condition except death itself.

With regard to the prostate, black seed is useful for both BPH and in preventing prostate cancer induction. One of the important ingredients in black seed oil, thymoquinone, promotes healthy apoptosis in prostate cells and therefore helps the body to regulate the size and health of the prostate.^17,18 Similar effects have been found in, for example, breast cancer, so TQ has a broad spectrum of applications.¹⁹

Cactus Flower
A couple of decades back, the herbal extract chrysin was introduced to the athletics and body building world as an answer to improving free testosterone levels and reducing the pathway (aromatase) that transforms testosterone to estrogen. Chrysin has some benefits, as long as one does not expect too much and is willing to focus on the anxiolytic qualities of the compound (found in passion flower). However, much more successful compounds for this purpose of increasing free testosterone, and so forth, have been found. One of these is an extract of cactus flower (Opuntia ficus-indica).

I ran across this almost a decade ago being sold in Germany and Israel for BPH,²⁰ but at the time could not find a reliable source of supply. Since then, a friend with whom I was working took this item and continued to dig until he found a reliable source that he could market as increasing serum free testosterone levels and reducing aromatase (reducing estrogen production and inhibiting the binding of dihydrotestosterone/DHT.) As my friend writes at his website, based on preliminary laboratory research, “Opuntia flower extract (1 mg/ml concentration) inhibited over 80% of the activity of 5-alpha reductase in human prostate tissue homogenate and inhibited over 80% of aromatase activity in human placenta tissue homogenate.”²¹ This particular product also contains supporting ingredients, such as an extract of stinging nettle root.

Some Prostate-Questionable Foods and Pharmaceuticals Now for a few items that men may want to remove from their daily habits or environment.

• Non-and low-fat milk (but not whole milk or other dairy products) intake by men is linked to higher rates of prostate cancer²²
• Long-term use of statins increases the risk of prostate cancer²³
• Oral contraceptive use is associated with prostate cancer—this refers to these contraceptives getting into the environment at large and not to use by one’s partner²⁴

Conclusion
There are protective foods, nutrients and herbs of which men should take advantage to maintain and regain prostate health as well as improve other parameters of health and performance. Omega-3 fatty acids and the active compounds found in red wine (grape skin anthocyanidins and other compounds, resveratrol, grape seed proanthocyanidins, quercetin), green tea (EGCG) and bitter melon are on this short list. More exotic are black seed and thymoquinone as well as cactus flower extract. For the most part, these can be characterized as special foods since they can be consumed over the long term and have few or no downsides even when consumed chronically in large amounts. Indeed, this should be the goal—a little prevention is always worth a whole lot of cure.

References

1. 1. 1. F. Hinman, Benign Prostatic Hypertrophy. New York: Springer-Verlag, 1983.
      2. Brasky TM, Darke AK, Song X, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr, Goodman GE, Minasian LM, Parnes HL, Klein EA, Kristal AR. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. J Natl Cancer Inst. 2013 Aug 7;105(15):1132– 41. doi: 10.1093/jnci/djt174.
      3. Experts slam omega-3 link to prostate cancer as overblown ‘scaremongering.’ http://www.nutraingredients.com/content/view/print/796071
      4. Ibid.
      5. http://www.foodnavigator-usa.com/news/printNewsBis.asp?id=65537
      6. Williams CD, Whitley BM, Hoyo C, Grant DJ, Iraggi JD, Newman KA, Gerber L, Taylor LA, McKeever MG, Freedland SJ. A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer. Nutr Res. 2011 Jan;31(1):1–8. doi: 10.1016/j.nutres.2011.01.002.
      7. http://zonediet.com/blog/2013/07/
      8. A glass of red wine a day keeps prostate cancer away?
      9. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Cancer Res. 2007 Sep 1;67(17):8396–405.
      10. Raina K, Singh RP, Agarwal R, Agarwal C. Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Cancer Res. 2007 Jun 15;67(12):5976-82.
      11. Tang SN, Singh C, Nall D, Meeker D, Shankar S, Srivastava RK. The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal. 2010 Aug 18;5:14. doi: 10.1186/1750–2187–5–14.
      12. Nerurkar P, Ray RB. Bitter melon: antagonist to cancer. Pharm Res. 2010 Jun;27(6):1049–53. doi: 10.1007/s11095–010–0057–2.
      13. Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB. Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model. Cancer Prev Res (Phila). 2011 Dec;4(12):2122–30. doi: 10.1158/1940–6207.
      14. TotalHealth Online: Going Wild With Bitter Melon for Blood Sugar Support
      15. Goodman A. High Marks for Nutritional Supplement in Patients with Localized Prostate Cancer. Value-Based Cancer Care. September 2013 Vol 4, No 7.
      16. Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. A doubleblind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer-the UK NCRN Pomi-T study. Prostate Cancer Prostatic Dis. 2014 Mar 11. doi: 10.1038/pcan.2014.6.
      17. Kaseb AO, Chinnakannu K, Chen D, Sivanandam A, Tejwani S, Menon M, Dou QP, Reddy GP. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer.Cancer Res. 2007 Aug 15;67(16):7782–8.
      18. Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2012 Feb 15;83(4):443–51. doi: 10.1016/j.bcp.2011.09.029.
      19. Rajput S, Kumar BN, Sarkar S, Das S, Azab B, Santhekadur PK, Das SK, Emdad L, Sarkar D, Fisher PB, Mandal M. Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer. PLoS One. 2013 Apr 17;8(4):e61342. doi: 10.1371/journal.pone.0061342.
      20. Palevitch D., Earon G., Levin I., Treatment of benign prostatic hypertrophy with Opuntia ficus-indica (L.) Miller. Journal of herbs, spices & medicinal plants. J. herbs spices med. plants 1993;2(1):45–49.
      21. http://cleanmachineonline.com/science/how-it-works/ drawing upon Jonas A, Rosenblat G, Krapf D, Bitterman W, Earon G, Neeman I. Efficacy of cactus flowers miller treatment in benign prostatic hyperplasia due to inhibition of 5a reductase activity, aromatase activity and lipid peroxidation. HerbaMed paper; undated.
      22. Park SY, Murphy SP, Wilkens LR, Stram DO, Henderson BE, Kolonel LN. Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multi-ethnic Cohort Study. Am J Epidemiol. 2007 Dec 1;166(11):1259–69.
      23. Chang CC, Ho SC, Chiu HF, Yang CY. Statins increase the risk of prostate cancer: a population-based case-control study. Prostate. 2011 Dec;71(16):1818–24. doi: 10.1002/pros.21401.
      24. Margel D, Fleshner NE. Oral contraceptive use is associated with prostate cancer: an ecological study. BMJ Open. 2011 Nov 14;1(2):e000311. doi:10.1136/bmjopen–2011–000311.

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Focus on the Prostate

Pollen extract is a special mixture of both water-soluble and fat-soluble compounds derived from various pollens, chiefly rye, and often marketed under the name Cernilton. Most people know of pollen extracts in conjunction with prostate health. This generally is associated with benign prostatic hyperplasia (formerly called hypertrophy), which involves a renewed growth in the number of prostate cells late in life.¹ Unfortunately, of men between the age of 40 and 59, nearly 60 percent can be shown to already be suffering from benign prostatic hyperplasia. This usually does not present a noticeable problem until after the age of 50; by the age of 80, however, some 85 percent of all men suffer from one or more symptoms of BPH. The primary effect of BPH is a progressive decrease in the ability to empty the bladder as the prostate enlarges and applies pressure to the urethra. The American Urological Association Symptom Index is now a standard assessment for BPH severity.

Prostatitis is really a catch-all term for several types of prostate problems.² It always involves inflammation of the prostate and may also include considerable pain, whereas BPH may not involve any pain at all (as opposed to discomfort). Prostatitis is fairly common in adult males and has been classified into four types. Only at most five percent of all cases consist of either acute or chronic bacterial prostatitis, i.e., cases in which infection and the aftermath of infection are the main issues. Non-bacterial prostatitis comprises 64 percent of cases and Prostatodynia makes up another 31 percent.

Non-bacterial prostatitis is the most common of the prostatic conditions, but its cause has not been isolated. It is characterized by an unusually high number and activity of inflammatory cells in the prostate. The resulting inflammation resembles that found in chronic prostatitis, but there is no history of infection nor do cultures (for bacteria) prove positive. Conventional medical treatments do not yield good results. Abstaining from alcohol and spicy foods helps in some cases.

Prostatodynia, which is most common in young and middle-aged men, presents many symptoms similar to the above, but lacks the excessive number of inflammatory cells. Just as nonbacterial prostatitis has some symptoms that are peculiar to it, so, too, does prostatodynia. In particular, pain and/or discomfort in the groin, perineum, testicles, lower back and penis seem to characterize this condition. Smooth muscle spasms in the prostatic portion of the urethra and in the neck of the bladder are at work here. The subsequent reflux of urine into prostatic and ejaculatory ducts causes a chemically-induced inflammation. Fatigue in the muscles in the pelvic region and emotional stress appear to be powerful contributory factors in prostatodynia.

Of these three conditions, BPH is what concerns most men. Prostate enlargement is strongly related to normal aging. Some of the factors involved are quite well understood. Nevertheless, there also is substantial disagreement about other issues. BPH can be called an aspect of male menopause because an increased ratio of estrogen to testosterone is active in BPH just as, conversely, in women passing through menopause the ratio of testosterone to estrogen increases. Testosterone, the “male” hormone, is at its peak during adolescence. It decreases thereafter, and the rate of decrease sharpens by about age 50. The decline in testosterone production typically calls into play the compensatory release of other hormones, which are stimulants to testosterone production. These cannot prevent the decline in testosterone levels, but they can lead to an elevated rate of transformation of testosterone into 5-alpha-dihydrotestosterone (DHT) and to the increased binding to and/or decreased clearance of DHT from prostate cells. Testosterone is converted to DHT by the enzyme 5-alphareductase. Ultimately, it is DHT’s actions that cause the enlargement of the prostate. DHT binds to specific receptors on the prostate cells, the alpha 1-receptors. It then is transported into the nucleus of these cells where it attaches to the DNA and ultimately turns on prostate growth.

How do pollen extracts work? Clinical trials with these extracts covering 12 weeks of treatment generally have produced improvements in cases of BPH and prostatodynia of between 60 and 88 percent when adequate dosages were administered and depending upon the severity of the starting condition. The first mechanism of action is smooth muscle relaxation, something that promotes the ability to urinate as spasms in the smooth muscle tissues are reduced. In animal studies, pollen extracts have been shown to inhibit urethral contraction, which facilitates the discharge of urine. Data in these studies is consistent with the observations that pollen extracts facilitate voiding of the bladder and reduce residual urine.

A number of clinical studies have shown that the pollen extracts reduce the size of the prostate in those individuals suffering from BPH. These data indicate that pollen extracts should either inhibit the formation of DHT by blocking the alpha-reductase enzyme, or act to block the binding of DHT to the alpha 1-receptor and thus improve the clearance of DHT from the prostate. Either mechanism could be effective in blocking the DHT-induced biological cascade that leads to prostate enlargement.

Inflammation, Immune Functions and the Liver

Inflammation underlies a large number of conditions, including several of those improved by pollen extracts. Evidence to support the anti-inflammatory action of the pollen extracts comes from both animal and clinical experience. Three animal studies indicated that pollen extracts exhibit anti-inflammatory activities. The first showed that pollen extracts inhibit the arachidonic acid cascade, a primary generator of free radicals in the tissues. The second indicated that orally administered pollen extracts counteract the inflammatory process found with artificially-induced liver damage in rats. The third showed that an induced inflammatory condition in rodents was significantly reduced by pollen extracts. It has been proven that pollen extracts are active in human subjects against inflammation. As noted already, several clinical studies also have shown that pollen extracts are an effective treatment for the inflammatory prostate conditions prostatitis and prostatodynia.

Mechanisms of action involving inflammation link pollen extracts to conditions that involve more than just the prostate. It has long been known that pollen extracts modulate the actions of the immune system. Many years ago, researchers showed that the water-soluble fraction selectively inhibits the growth of some prostate cancer cell lines. Later research was published, which showed that a compound found in the water-soluble fraction does not merely inhibit prostate cancer cell growth, but actually causes the death of these cells.³ These results were found in vitro studies (that is, in cultured cells), yet they provide promise for research to come.

The liver protective effects of pollen extract, which have been researched over the years, have received another boost from scientists in the Ukraine. In this case, the tests were in vivo, that is, with animals using a special extract of bee-collected pollen. First, it was established that small doses of x-ray radiation cause oxidative damage to fats in the liver (lipid peroxidation) and that this damage activates antioxidant enzyme protective systems. Next, it was discovered that the introduction of pollen extract into the animals’ systems normalized the activity of the glutathione enzyme system, one of the most important of the body’s in-built antioxidant systems.⁴

Immune Functions for the Heart and Recovery

Surprisingly, pollen extracts may possess the ability to protect the heart against certain types of assault. The ability of pollen extract to protect the cardiovascular system against free radical damage was demonstrated over a decade ago. Now, taking research in a quite different direction, it has been shown that the damage to the heart that can be caused by excess adrenaline also can be reduced by the use of the water-soluble fraction of the pollen extract.⁵ Researchers admit that they do not have a good explanation for how this cardio-protection is achieved; yet their findings open up the possibility for totally new uses for pollen extract in the future!

Similar to the cardiac protection afforded is general immune protection. Although primarily known as treatments for BPH, flower pollen extracts have been thoroughly studied for their anti-inflammatory properties and their abilities both to boost flagging immune functions.⁶ One of the findings of this research is that pollen extracts act as immuno-regulators and can reduce immune hyperactivity. The serious reader can work through the earliest literature on the development of pollen extracts in Europe and discover that the early uses of pollen extracts were a) for recovery during convalescence and b) recovery from sports exertions.

Conclusions
Pollen extracts have turned out to be surprisingly versatile in their range of health benefits. Along with the prostate benefits, there further are general immune benefits, effects on cancer, the liver, sports recovery and much more.⁷ Every man aged 50 and above probably should consider a pollen extract supplement as insurance against BPH and other prostate issues. However, given the range and variety of benefits associated with pollen extracts, there is a good argument to be made for men to supplement with pollen extracts for general protection against over-training and or supporting immune imbalance.

References

1. 1 F. Hinman, Benign Prostatic Hypertrophy. New York: Springer Verlag, 1983.
2. 2 E.M. Meares, Jr., “Prostatitis and Related Disorders,” in Campbell’s Urology, 6th edition, ed. by P.C. Walsh, et al. Philadelphia, PA: W.B. Saunders Company, 1992, pp. 807–22.
3. 3 Roberts KP, Iyer RA, Prasad G, Liu LT, Lind RE, Hanna PE. “Cyclic hydroxamic acid inhibitors of prostate cancer cell growth: selectivity and structure activity relationships.” Prostate 1998 Feb 1; 34(2):92–9.
4. 4 Bevzo VV, Grygor’eva NP. [Effect of bee pollen extract on glutath one system activity in mice liver under X-ray irradiation]. [Article in Ukrainian] Ukr Biokhim Zh 1997 Jul-Aug; 69(4):115–7.
5. 5 Polanski M, Okon K, Przybylo R, Frasik W. Cardioprotective properties of hydrophilic pollen extract (HPE). Polish Journal of Pathology 1998; 49(2):109–12.
6. 6 Samochowiec L, et al., “General immunological properties of fat soluble (Cernitin GBX) and water-soluble (Cernitin T60) pollen extracts,” European Journal of Pharmacology 183, 3 (1990) 906.
7. 7 Graminex_Clinical_Studies_Index found at http://www.readbag.com/pollenaid-pollenaid-file-graminex-clinical-studies-index.

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The prostate is a golf ball-sized gland located between the bladder, rectum, and penis in the male genitourinary system. It surrounds the urethra, which is the passageway for urine from the bladder and sperm from the testis. The prostate produces and secretes a milky alkaline fluid that makes up about 25 percent of the volume of sperm. Prostatic fluid provides energy for sperm on the journey to the female egg, contains enzymes required to break through proteins, and contains a natural antibiotic to help prevent infections.

Why Does the Prostate Gland Enlarge?
The prostate gland grows slowly from birth to puberty. Between puberty and age 30 it grows more rapidly as the endocrine system enters adulthood. Between the ages of 30 and 45 the size of the prostate typically remains relatively unchanged. However, the prostate gland often begins to grow again for most men after the age of 45. Generally, the prostate will continue to grow for the rest of a man’s life. There is no known physiological reason for the enlargement of the prostate but the cause is believed to be due to an increase in androgen hormones in the body, specifically DHT.

What Are the Signs? How Is It Detected? When Should It Be Treated?
Prostate enlargement is generally associated with clinical symptoms like difficulty urinating or ejaculating, urinary frequency or urgency, incomplete emptying of the bladder, incontinence, or terminal dribbling. It is recommended that men over the age of 40 have yearly prostate exams as a preventative screening technique. If the prostate begins to harden and enlarge a preventative strategy should be implemented to help reduce or prevent further growth and development of symptoms.

Naturopathic Treatment for Prostate Enlargement

Our goal is to determine the underlying causes of prostate enlargement for each patient and formulate a treatment strategy that addresses those underlying causes. Diets high in pesticides, chemicals, cholesterol, and alcohol are associated with prostate enlargement. Diets low in essential nutrients like zinc and essential fatty acids are also linked to prostate enlargement. Several botanicals, like saw palmetto, and nutritional supplements have been shown to reduce prostate enlargement by reducing the formation of DHT. Naturopathic treatments are also indicated for people with current urinary symptoms. Hydrotherapy, botanical medicine, acupuncture, massage, and homeopathics have been used successfully for decades to treat symptoms of prostate enlargement. If you are interested in more information please consult your naturopathic physician about individualized treatment.

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What are the symptoms?
In the initial stages, a patient may experience increased urinary frequency during the day, nocturia (getting up at night to go to the toilet) and the sensations of not being able to empty completely. As the condition becomes more advanced, there is an increase in the obstructive symptoms characterized by the following: weak urine stream, difficulty starting urination, straining to urinate, stopping and starting again while urinating, dribbling at the end of urination, urgency, and pain on urination. If the BPH symptoms are severe, it may result in the inability to urinate. This can cause severe pain and discomfort. In addition, if urine is retained in the bladder for long periods of time, this can lead to urinary tract infections, bladder or kidney damage, or bladder stones.³

What is the primary risk factor?
It appears that age itself is the primary risk factor for developing symptoms associated with BPH.

Is there a link between hormonal changes during aging and benign prostate hypertrophy?

The exact cause of BPH is unclear, although researchers believe it may be caused by hormonal changes that occur during the aging process.

• Decreased testosterone levels: One theory is that as a man ages, the amount of testosterone in his blood decreases, leaving a higher proportion of estrogen in his blood. The disproportion of estrogen may contribute to cell growth within the prostate gland.
• Increased levels of dihydrotestosterone (DHT): Another possible theory is that as a man ages there is a hormonal change involving the accumulation of DHT, a by-product of testosterone in the body. If levels of DHT accumulate in the prostate,
• overgrowth of cells in the prostate can occur.³

What are the possible treatments?
Treatment for BPH depends on the severity of symptoms. Medications are the most common way to control mild to moderate symptoms of BPH. Watchful waiting, also known as observation, expectant therapy or deferred therapy, is often the preferred approach for men with mild symptoms who aren’t bothered by them.

—Pharmaceutical Medications
The most commonly used medications are alpha-adrenergic blocking agents which work by relaxing the smooth muscle tissue. Since there is a large number of alpha-adrenergic receptors in the bladder, the bladder neck and prostate gland, they cause relaxation and reduced tone, which then allows urinary flow. Although these drugs have been found to be effective, patients may experience side effects including headache, dizziness, low blood pressure, fatigue, weakness, and difficulty breathing. These are due to the fact the drug works on all smooth muscle tissue in the body, not just the prostate. The long-term risks and benefits have not been studied.&sup4;

The other common drug treatment is enzyme (5-alpha reductase) inhibitors that work directly on the endocrine system. They prevent the conversion of testosterone to the hormone dihydrotestosterone (DHT) and as a result reduces the size of the prostate itself. However, while studies have shown a decrease in symptoms it does not correlate with urinary flow rate and volume. In many cases, a treatment period of six months is necessary to see if the therapy is going to work. The side effects include reduced libido, impotence, breast tenderness and enlargement, and reduced sperm count. Again, these effects are due to the fact the drug may reduce the total testosterone in the body and the effects are not restricted to the prostate gland. The long-term risks and benefits have not been studied.

—Surgical Treatment Most doctors recommend removal of the enlarged part of the prostate as the best long-term solution for patients with BPH. With surgery for BPH, only the enlarged tissue that is pressing against the urethra is removed; the rest of the inside tissue and the outside capsule are left intact. Surgery usually relieves the obstruction and incomplete emptying caused by BPH.1 Surgery used to be the most common way to treat BPH. Today, its use is declining because of new medications and minimally invasive treatments. Surgery is usually used when non-surgical treatments fail or if there are BPH complications.²

—Complementary Medicines The principle goal of BPH treatment is to reduce excessive cell growth by inhibiting the conversion of testosterone into the more potent hormone dihydrotestosterone (DHT) and so preventing estrogen from attaching to receptors in prostate tissue.

Some supplements are intended to reduce symptoms while others will provide nutritional support. The combination of glycine, alanine, and glutamic acid can reduce urinary urgency, urinary frequency, and delayed micturition (initiation of flow). Beta-sitosterol may also help reduce symptoms of BPH. Betasitosterol also lowers cholesterol, which is important since high cholesterol levels can contribute to prostate hypertrophy. Flaxseed oil is a good source of the essential fatty acid (EFA) alphalinolenic acid (an omega-3 fatty acid). It is well-known that zinc is an important mineral for male health. Why? It may be related to the fact that zinc inhibits 5 alpha reductase and therefore lowers DHT production.

The most well studied herb is saw palmetto (Serenoa serrulata). Saw palmetto is a 5-alpha reductase inhibitor that inhibits the conversion of testosterone to DHT in the prostate, has an antiestrogenic effect, and helps improve all symptoms of BPH. Both pygeum (Pygeum africanum) and stinging nettles (Urtica dioica) may also reduce BPH symptoms although research is less conclusive.

Latest research— UrologicPros
One of the most recent exciting breakthroughs in this area has been the development of a unique herbal and mineral preparation, UrologicPros™, which has been clinically proven to be effective in reducing the urinary symptoms associated with BPH.

UrologicPros contains a patented formulation of herb ingredients, crateva and horsetail, which has been shown to be effective in treating the symptoms of overactive bladder in men and women with urinary incontinence. In this formulation, it has been combined with saw palmetto, zinc and selenium, which support prostate health.

In the most recent study, 33 men were asked to take UrologicPros (as an oral supplement) each day for a period of three months. Symptoms were assessed using a diary of urinary frequency (day and night) and the International Prostate Symptom Score.

There was a significant gradual reduction in daytime urinary frequency over the three months, for those with moderate and severe symptoms. There was also a significant reduction in episodes of nocturia over the three months.

There was an overall 40 percent reduction in symptoms over the three months. The median reduction (of individual results) was 45 percent with a range from (0–81 percent improvement). The greatest improvement was seen relating to nocturia, and urinary flow (particularly the symptom “difficulty emptying bladder”). The positive effect of the treatment on nocturia was seen within the first month, whereas the urinary flow symptoms improved most significantly after two months of treatment. There was also a significant improvement in quality of life reported as well. At completion of the study, 29 of the 33 subjects (88 percent) wanted to continue with treatment.

Figure 1: Average daytime urination frequency after treatment with UrologicPros

Figure 2: Average episodes of nocturia after treatment with UrologicPros

The inclusion of whole, fresh, unrefined, and unprocessed foods including fruits, vegetables, whole grains, soy, beans, seeds, nuts, olive oil, and cold-water fish (salmon, tuna, sardines, halibut, and mackerel) may help. It is important to remember that eating organic food helps reduce exposure to hormones, pesticides, and herbicides (which affect testosterone and estrogen balance). Optimal hormonal balance will occur in the absence of refined sugar and flour, dairy products, refined foods, fried foods, junk foods, and hydrogenated oils. There will be less stress on the bladder system itself if the amount of alcohol (particularly beer), and caffeine in the diet is reduced.

In summary, at present we have a limited understanding of the pathology underlying the symptoms associated with an enlarged prostate as men age. There are no specific pharmacological medications specific for the prostate (or drugs that do not have unwanted side effects in the body). Based on its current success rate, surgery should always be considered a last option when all other treatments have failed. However, there is increasing research directed at the role for individual and combined nutraceuticals in the management of urinary tract problems including BPH. Therefore, natural treatments should be considered as the first line of defense on the treatment of benign prostate hypertrophy.

References:

1. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, NIH Publication No. 04–3012, Prostate Enlargement.
2. Mayo Clinic. Enlarged prostate (BPH) guide.
3. E Drug digest. Begin Prostate Hypertropy. www.drugdigest.org/DD/HC/Treatment/0,4047,550246,00.html &e=14911
4. Urology Channel. Prostate.

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