References

1. Centers for Disease Control and Prevention: Interactive Atlas of Heart Disease and Stroke. Accessed on November 24, 2021
2. Amini, M., Zayeri, F. & Salehi, M. Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017. BMC Public Health 21, 401 (2021).
3. A. C. Razavi, et al.. Early contributors to healthy arterial aging versus premature atherosclerosis in young adults: The Bogalusa Heart Study. Journal of the American Heart Association. October 5, 2021.
4. J. Fuhrman. Do angioplasty and stents improve survival? Studies expose limitations of the popular heart procedure. Very Well Health. Updated on December 4, 2019 and medically reviewed by Richard Fogoros, M.D.
5. Centers for Disease Control and Prevention. Underlying Cause of Death, 1999-2019. CDC WONDER Online Database. Atlanta, GA: 2018.
6. S. S. Virani, A. Alonso, H. J. Aparicio, E. J. Benjamin, M. S. Bittencourt, C.W. Callaway, et al. Heart disease and stroke statistics – 2021 update: A report from the American Heart Association. Circulation. 0221;143:e254-e743.
7. C. D. Fryar, T-C Chen, X. Li. Prevalence of uncontrolled risk factors for cardiovascular disease: United States, 1999-2010 [PDF-494K]. NCHS data brief, no.103. Hyattsville, MD: National Center for Health Statistics: 2012.
8. T. Thum, SARS-CoV-2 receptor ACE2 expression in the human heart: Cause of the post-pandemic wave of heart failure? European Heart Journal. 2020 May 14;41(19):1807-1809. Published online 2020 May 8.
9. C. Bens. Special Report: An emerging health crisis exposed by the COVID pandemic, TotalHealth. March 2021.
10. Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning Circulation. 2021;144:A10712 8 Nov 2021
11. Baylor College of Medicine. “Why the heart does not repair itself: New insights.” ScienceDaily, 5 June 2017. https://www.sciencedaily.com/releases/2017/06/170605121301.htm.
12. J. Salazar. Is the COVID-19 Vaccine linked to heart problems like myocarditis and pericarditis in young people? Connecticut Children’s Medical Center. June 7, 2021: updated June 16, 2021. https://www.connecticutchildrens.org/coronavirus/is-the-covid-19-vaccine-linked-to-heart-problems-like-myocarditis-and-pericarditis-in-young-people/
13. National Center for Biotechnology Information. PubChem Pathway Summary for Pathway R-HSA-73894, DNA Repair, Source: Reactome. Accessed Mar. 1, 2022.
14. C. D’Aniello, F. Cermola, E. J. Patriarca and G. Minchiotti, Vitamin C in stem cell biology: Impact on extracellular matrix homeostasis and epigenetics. Environmental Stimulus on Stem Cell Behaviour. 20 April 2017.
15. A. Khan, H. Dawoud, T. Maliniski. Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1, 25-dihydroxy vitamin D3 – clinical implications for cardiovascular disease. International Journal of Nanomedicine. 19 January 2018, Volume 2018:13; 455-466
16. G.-R. Xu, C. Zhang, H.-X. Yang, J.-H. Sun et al. Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-kB signaling pathway. Biomedicine & Pharmacotherapy, 126:June 2020.
17. V. Zozina, S. Covantev, O. Goroshko, L. Krasnykh, & V. Kukes, Coenzyme Q10 in cardiovascular and metabolic diseases: Current state of the problem. Current Cardiology Reviews, 14:3, 2018.
18. J. DiNicolantonio, J. Liu, & J. O’Keefe, Magnesium for the prevention and treatment of cardiovascular disease. Statistics from Altmetric.com.
19. L Yu, Q. Li, B. Yu, Y. Yang et al. Berberine attenuates myocardial ischemia/reperfusion injury by reducing oxidative stress and inflammation response: Role of silent information regulator 1. Oxidative Medicine and Cellular Longevity. 2016: 1689602.
20. G. Leoni & O. Soehnlein, (Re) Solving repair after myocardial infarction. Front Pharmacology; 66 November 2018.
21. R. Fassett & J. Coombes. Astaxanthin in cardiovascular health and disease. Molecules. 2012 Feb;17(2):2030-2048.
22. T. Qaradakhi, L. Gadanec, K. McSweeney, J. Abraham, V. Apostolopoulos & A. Zulli, The Anti-inflammatory effect of taurine on cardiovascular disease. Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia, Nutrients 2020:12(9), 2847.
23. M. Ash. The next generation vitamin E: How tocotrienols prevent and repair heart, brain and liver disease. Clinical Education. Thursday, 16 May 2013.
24. T. Okamoto, N. Akita, M. Terasawa, T. Hayashi, & K. Suzuki. Rhamnan sulfate extracted from Monostoma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells. Journal of Natural Medicines. 73, 614-619(2019).
25. Sakai C, Ishida M, Ohba H, Yamashita H, Uchida H, et al. (2017) Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells. PLOS ONE 12(11): e0187934.
26. Lagunas-Rangel FA and Bermúdez-Cruz RM (2020) Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells.
27. Steven R Gundry, mRNA COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning’ , Circulation 8 November 2021,
28. Raghavan S, Kenchappa DB and Leo MD (2021) SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity. Front. Cardiovasc. Med. 8:687783. doi: 10.3389/fcvm.2021.687783.
29. Hardell, L., Carlberg, M.”[Comment] Health risks from radiofrequency radiation, including 5G, should be assessed by experts with no conflicts of interest“. Oncology Letters 20.4 (2020):
30. Luiking YC, Engelen MP, Deutz NE. Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care. 2010;13(1):97-104. doi:10.1097/MCO.0b013e328332f99d.
31. Steven R Gundry, mRNA COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning’ , Circulation 8 November 2021, `#
32. Cincinnati Children’s Hospital Medical Center. “Biology of mending a broken heart: Scientists test way to stop heart damage after cardiac injury.” ScienceDaily, 28 September 2017.
33. Kamierczak-Baraska, Julia et al. “Nutrition Can Help DNA Repair in the Case of Aging.” Nutrients vol. 12,11 3364. 1 Nov. 2020, doi:10.3390/nu12113364.
34. Rizzo C, Carbonara R, Ruggieri R, Passantino A and Scrutinio D (2021) Iron Deficiency: A New Target for Patients with Heart Failure. Front. Cardiovasc. Med. 8:709872. doi: 10.3389/fcvm.2021.709872
35. Kalayoglu MV, Libby P, Byrne GI. Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA. 2002 Dec 4;288(21):2724-31. doi: 10.1001/jama.288.21.2724. PMID: 12460096. https://pubmed.ncbi.nlm.nih.gov/12460096/
36. 3Chan, T.H., “Preventing Heart Disease”. School of Public Health, Harvard, January 2022,
37. Alves QL, Camargo SB, Silva DF (2019) Role of Nutraceuticals in the Prevention and Treatment of Hypertension and Cardiovascular Diseases. J Hypertens Manag 5:037. doi.org/10.23937/2474-3690/1510037
38. Cummings JL, Morstorf T, Zhong K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther. 2014 Jul 3;6(4):37. doi: 10.1186/alzrt269. PMID: 25024750; PMCID: PMC4095696.
39. Gustafson C. Dale E. Bredesen, md: Reversing Cognitive Decline. Integr Med (Encinitas). 2015;14(5):26-29.
40. Mollace V, Rosano GMC, Anker SD, Coats AJS, Seferovic P, Mollace R, Tavernese A, Gliozzi M, Musolino V, Carresi C, Maiuolo J, Macrì R, Bosco F, Chiocchi M, Romeo F, Metra M, Volterrani M. Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review. Nutrients 2021 Jan 17;13(1):257.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

Conclusion and Final Thoughts

1. Stages of prevention- A recent study from Harvard University and reprinted in the Journal of the American College of Cardiology explains the three stages of prevention of heart disease. These stages include secondary prevention, primary prevention and primordial prevention. These three stages include addressing known risk factors and providing treatment prior to any event, based on the avoidance of known risk factors such as smoking, lack of exercise, high blood pressure or poor eating habits. The goal of this article is to establish new stages of prevention based on the repair of damaged cardiovascular tissues. Scientific evidence suggests that this is possible and now more evidence of the effectiveness of this approach can be gathered in doctor’s offices, clinics and hospitals reporting their success, and having it further validated in clinical trials.³⁶

2. The increasing use of nutraceuticals- The use of nutraceuticals in the prevention and treatment of cardiovascular disease has been well established for many decades. A recent study (2019) with 119 references, has documented success in the mitigation of many cardiovascular risk factors such as high blood pressure and the delay of increased risk factors such as the development of plague or hardening of the arteries. The nutritional components featured in this article include vitamin C, flavonoids, garlic and lycopene, which all have antioxidant and anti-inflammatory properties able to modulate various physiological pathways. This article expands on this list, going far beyond these prevention pathways to include cellular repair and replacement pathways which can modulate the cell replacement process pathways.³⁷

3. The combination of nutraceutical therapies- One of the biggest hurdles with the advancement of medicine towards prevention and cellular repair is the use of the gold standard double-blind placebo-controlled study. These studies have traditionally featured monotherapy approaches for both prescription and nutraceutical examinations. The evidence is continuously pointing to the failure of this approach and one classic example is the resent efforts to find an effective treatment for Alzheimer’s Disease. The Cleveland Clinic reviewed all studies for the treatment of Alzheimer’s over a twenty-year period and found the failure rate to be 99.6%.³⁸ On the other hand, a therapy developed by Dale Bredesen, MD using a multi-therapy approach was successful in 90% of the patients. The study involved ten people diagnosed with various stages of Alzheimer’s, and used thirty-eight factors known to influence the development of this illness. Subsequent experience has validated the success of the Bredesen Protocol.³⁹

This challenge to the clinical trial process on the topic of cardiovascular disease is well illustrated by a study in 2021 published in Nutrients- Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive review.⁴⁰ What is clearly needed is a reform of the gold standard for medical studies to allow for, if not encourage, the use of multi-factor treatment therapies not only in clinical trials, but also for studies in doctor offices. We need to find these science-based therapies and put them into practical use as soon as possible to save lives and reduce the cost of waiting for therapies to be declared perfect before encouraging their use.

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

Emerging Cardiovascular Damage Reduction Strategies

New strategies to prevent and repair cardiovascular cell damage are emerging on a regular basis in research being conducted by scientists in universities and other health and medical institutions. The following studies are just a few of the more promising examples of some of this research.

mRNA Vaccines cardiovascular damage
The new mRNA vaccines have now been shown to dramatically increase endothelial inflammation and the risk of acute coronary syndrome (ACS). This condition can occur more rapidly with the influence of this viral related damage then might usually be the case. This type of vaccination seems to induce damage to heart cells leading to cell death and myocardial infraction (heart attack) in people with no previous history of this disease. This damage can be found and measured with the PULS Cardiac Test.³¹

The Wnt/B-catenin signaling pathway
Scientists may have found a way to preserve heart function after heart attacks or for people with inherited heart defects called congenital cardiomyopathies. Researchers report that after simulating heart injury in laboratory mouse models, they stopped or slowed cardiac fibrosis, organ enlargement and preserved heart function by blocking a well-known molecular pathway known as the Wnt/B-catenin pathway. The Wnt/B-catenin signaling pathway is involved in several of the body’s fundamental biological processes. After heart injury, however, Wnt/B-catenin signaling ramps up in cardiac fibroblast cells to cause fibrosis, scarring and harmful enlargement of the heart muscle, according to the researchers. This finding may also apply to cellular damage occurring due to the COVID-19 infection as well as the COVID-19 vaccinations. This might also explain the connection to the Galectin-3 blood marker, as well as the ability of Modified Citrus Pectin to stop and even reverse this fibrotic reaction.³²

Micronutrients for the repair of DNA in the aging population
Prolonged deficiency in one or more micronutrients may lead to cardiovascular and/or neurodegenerative disorders. Keeping micronutrients at adequate levels is especially important for seniors. They are prone to deficiencies due to age-associated functional decline and often to a diet low in essential nutrients. Moreover, lack of micronutrients has an indirect impact on the genome. Low levels of essential nutrients can reduce the activity of antioxidant enzymes, and therefore inhibit the efficiency of defense against free radicals which can lead to the formation of DNA lesions. The more DNA damage in the genetic material, the faster aging will occur at the cellular level leading to a higher risk of pathological processes (e.g., carcinogenesis). Supplementation of crucial antioxidative micronutrients such as selenium, zinc, vitamin C, and vitamin E seems to have the potential to positively influence the condition of an aging organism, including minimizing inflammation, enhancing antioxidative defense, and limiting the formation of DNA lesions.³³

Iron deficiency impacts the heart
Iron deficiency (ID) and anemia (individually or together) leading to low hemoglobin and hematocrit, impact oxygenation and severity of COVID. This is one of the most frequent comorbidities in patients with heart failure (HF). ID is estimated to be present in up to 50% of outpatients and is a strong independent predictor of HF outcomes. ID has been shown to reduce quality of life, exercise capacity and survival, in both the presence and absence of anemia. Beyond its effect on hemoglobin, iron plays an important role in oxygen transport and in the metabolism of cardiac and skeletal muscles.

Mitochondria are the most important sites of iron utilization and energy production. These factors clearly have roles in the diminished exercise capacity in HF. Oral iron administration is usually the first route used for iron repletion in patients. However, the data from the IRONOUT-HF study do not support the use of oral iron supplementation in patients with HF and a reduced ejection fraction, because this treatment does not affect peak VO2 (the primary endpoint of the study) or increase serum ferritin levels. The FAIR-HF and CONFIRM-HF studies have shown improvements in symptoms, quality of life and functional capacity in patients with stable, symptomatic, iron-deficient HF after the administration of intravenous iron (i.e., FCM).³⁴ Nutritional sources of bioavailable iron are advisable whenever possible, in order to avoid iron overload, which is pro-inflammatory and can lead to oxidative stress.

The bacteria chlamydia pneumonia can impact plague development
A bacterium that causes colds, sinus infections, bronchitis, asthma or pneumonia may also contribute to the development of heart disease. Chlamydia pneumonia can be latent in the body, as many viruses are, and can cause arterial inflammation as many toxins do. As is the case with toxins this bacterium can encourage the development of plague in arteries. In one study chlamydia pneumonia was found in 79% of people with carotid artery plague compared to only 4% of people who had no plague. Doctors who find inflammation markers such as fibrinogen, homocysteine, C-reaction protein or ferritin should also check for the presence of chlamydia pneumonia. This can best be accomplished by measuring PCR for the presence of chlamydia antibodies.³⁵

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

Understanding and Supporting the Repair Process Elements

1. Nutrition- At the beginning of this special report we mentioned the need to follow a plant-based Mediterranean Diet. However, in most cases this may still not allow most people to achieve optimum nutritional levels. Most functional medicine doctors also recommend a multiple vitamin and mineral supplement to satisfy the need for various micronutrients. Another way is to consume a green powered drink in a morning smoothie. This can add 7-9 helpings of fruits and vegetables without including the extra sugar, as well as provide the necessary micronutrients.

2. Detoxification strategy- Toxins from many sources can cause DNA damage, over time, if it has not been repaired effectively. This DNA damage accumulates and can be measured by the 8-OHgD urine test previously mentioned. This damage creates a challenge for the DNA repair process and can be partially addressed with a high-quality detoxification program. One such program is called Clear Change provided by Metagenics. Your functional medicine doctor may have other options, but this program by Metagenics is one of evidence-based detoxification programs available.

3. Anti-viral strategy- Viruses can enter the body at any time and keeping them in check helps to allow the DNA damage repair process to be more effective. This should be controlled by several of the nutraceuticals mentioned in this article including vitamin C, vitamin D, zinc, quercetin and olive leaf extract.

4. Anti-inflammatory strategy- Inflammation is also a constant threat that needs to be controlled to optimize the DNA damage repair process. Several of the nutrients in this protocol help to achieve this including vitamin C, Specialized Pro-resolving Mediators, curcumin and molecular hydrogen.

5. Energy development- Cells need a lot of energy to ensure all cellular processes function in an efficient and effective manner. The nutrition in this protocol should be able to ensure this is possible due to the addition of key nutracueticals including magnesium, CoQ10 and berberine.

6. Senolytic management- Dead or damaged cells can sometimes accumulate in the body and should be periodically removed in order to protect other cellular processes. There are several products that can assist in this dead cell removal process including a product from Life Extension called Senolytic Activator. The product uses Bio-Fisctin, Theaaflavins and Bio-Quercetin to accomplish this removal process on an occasional basis.

7. Spike protein detoxification- The COVID-19 vaccinations have been shown to cause the replication of spike proteins, which can cause damage to blood vessels and most organs in the body. This can put a serious strain on the immune system and impede the effectiveness of this DNA cardiovascular repair process. Fortunately, many of the nutrients mentioned in this article have been shown to reduce the influence of these spike proteins. To determine if someone feels they need more support in this spike protein detoxification process please access the link to the Spike Protein Detox Guide from the World Council of Health.²⁸

8. Plaque removal and lesion stability- Both of these items are part of this cellular repair program and need not further attention.

9. Radiation exposure- The final optimization consideration is exposure to electromagnetic radiation such as X-rays, computers, cell phones and cell phone towers. This a special form of toxin that cannot be seen and also accumulates in the body with each exposure. The new 5G system is especially dangerous due to the dramatic increase in information being transmitted through the towers and into our homes and bodies.²⁹ A study explaining this danger and who to minimize it can be found in this link: Radiation The Silent Killer.

10. Increase nitric oxide- Nitric oxide causes blood vessels to widen and thus reduce the risk of a stroke or heart attack. It also stimulates the release of certain hormones, such as insulin, and human growth hormone needed for the repair of cells in the cardiovascular system. Foods such as beets help produce nitric oxide, as do nutritional supplements such as L-citrulline and L-arginine. A powdered product that contains these and other similar NO enhancers can play an important role in the repair of damaged cells in the cardiovascular system.³⁰

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

How to Measure the Early Stages of Cellular Deterioration

There are several proven assessment tools that can be used to determine if cells are moving towards chronic illness such as heart disease or heart damage caused by COVID infection or vaccine injections.

1. Vitamin D3– This blood test measures the level of vitamin D3 in the blood, which is crucial for the prevention and treatment of many diseases. VitaminD3 has been shown to activate many cancer prevention genes. Women with high levels of vitamin D3 (60-90 ng/ml) have an 82% lower risk for breast cancer. Vitamin D3 has also been shown to be very useful in the prevention and treatment of heart disease and viral infections.

2. GlycoMark test– This is an easier and faster way to assess the after–meal influence of glucose increases. In one draw, it can determine the 90–day pattern of glucose increases after meals with either 1,5–AG from serum or EDTA plasma blood sample.

3. Homocysteine– This is a great test to determine if the body has adequate levels of B vitamins, especially B6, B12 and folic acid. Deficiencies in these vitamins often indicate future mental challenges, hormone related diseases, potential birth defects, and cardiovascular system inflammation many other health challenges.

4. C–reactive protein– Inflammation is involved in many chronic diseases and can provide an early warning for heart disease and many other chronic diseases. Inflammation is often caused by the presence of free radicals in the body, which are molecules with an unpaired electron. High C–reactive protein levels are an early warning sign for heart disease, cancer, and many other chronic illnesses.

5. 8–OHgD test– Damage to cellular DNA is caused by toxins. Toxins such as chemicals in air, water or food, as well as various forms of radiation, can accumulate in the body. This accumulated level of toxins can lead to SNP’s (Single Nucleotide Polymorphisms) and damage to the DNA in the nucleus of our cells. The urine test 8–OHgD can measure the extent of this damage, thus providing an early warning of disease including cancer.

6. Galectin 3– This fibrosis molecule is found in our blood in small amounts. However, an elevation of this molecule can indicate the possible growing evidence of heart failure, inflammation, and cancer. Galectin 3 is found to be over–expressed on the surface of cancer cells, and actually helps the cancer cells to stick to one another. It also circulates in the blood, indicating that cancers are attempting to spread or metastasize. Because it can indicate the possibility of multiple diseases, including cardiac related illness, it should not be used alone to measure the presence or the spread of cancer or heart disease.

7. Oxygen test– A finger oxygen meter can measure circulating oxygen. Oxygen is crucial to the production of energy in the mitochondria where oxygen and glucose are combined. If oxygen levels are low, then the mitochondria do not produce enough energy and cells are not able to function properly. Finger meters use a 100–point scale and the desired level is from 96 to 100. As the level of oxygen drops, the seriousness of the cellular challenge increases. Circulatory restriction is usually the primary cause of reduced oxygen levels, although the presence of the Corona Virus is also a possible cause.

8. Cortisol– Cortisol is a steroid hormone released by the adrenals when the body is experiencing stress. There are many other reasons why cortisol levels can fluctuate, however stress is one of the most significant reasons. Cortisol increases blood sugar, suppresses the immune system, fights inflammation, and inhibits bone formation.

9. Vascular Endothelial Growth Factor (VEGF)– This test measures the amount of endothelial growth factor in our blood, which helps to encourage the growth of new blood vessels. VEGF increases when the body needs more oxygen, which is why the lungs often show higher levels than other parts of the body. In most situations new blood vessels are not necessary. However, when a tumor is beginning to form VEGF levels will increase in order to produce the new blood vessels needed. Elevated VEGF levels may occur before most cancer tests can actually detect the presence of cancer cells.

10. Gamma–Glutamyl Transferase (GGT)– Elevated serum levels of GGT are markers of oxidative stress, often associated with factors such as increased alcohol consumption, heavy metal exposure, heart disease and diabetes. This enzyme is found in many organs in the body, with higher concentrations found in the liver where it helps to deliver cysteine for the intercellular synthesis of glutathione, one of the bodies most important antioxidants. Elevated levels of GGT can also be associated with a higher risk of cancer.

11. Magnesium RBC– This the best test to measure the level of magnesium in the body. Magnesium has many responsibilities, but one of the most important ones is its ability to transport glucose and insulin into cells to be used as energy. Circulating glucose can cause diabetes and damage to arteries, possibly resulting in stroke and heart disease. It can also contribute to the formation and feeding of cancer cells. Higher levels of magnesium can help to prevent cancer, heart disease and many other chronic illnesses.

12. Vitamin C– This blood test measures Vitamin C levels. This vitamin is a powerful, water–soluble antioxidant that supports our immune function by shielding the DNA in our cells from free radical damage. It also reduces free radical damage in our organs and other tissues, by providing an electron to free radicals that are missing an electron and trying to steal an electron from our healthy cells.

13. Coenzyme Q10– CoQ10 comes in two forms, Ubiquinone and Ubiquinol. Its primary functions are to boost energy levels on the mitochondria of our cells, and provide antioxidant protection for the DNA in the nucleus of our cells. CoQ10 is therefore crucial to the function of the liver, which detoxifies our body and helps to manufacture key nutrients needed to support our immune system. CoQ10 is especially important to organs such as the heart, liver, kidneys, lungs and pancreas.

14. Fibrinogen– Fibrinogen is a glycoprotein complex, made in the liver. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin–based blood clot. It can help stop bleeding, but also be a key factor in plaque production.

15. D–dimer– This test looks for D–dimer in the blood; a small protein fragment that can cause clots. These clots can cause deep vein thrombosis, pulmonary embolism or stroke. They can also be used to determine is a COVID–19 infection or vaccine is causing blood clots to form within ten days of diagnosis or injection.

16. Omega 3/6 ratio– This blood test measures the ratio of omega 3 to omega 6 fatty acids in the body. Omega 3 is anti–inflammatory while omega 6 is pro– inflammatory. Too much omega 6 means the body is vulnerable to illnesses such as heart disease, cancer, flu and other chronic illnesses. The ideal ratio is one to one.

17. Prothrombin Time Test and INR (PT/INR)– A prothrombin time test measures how long it takes for a clot to form in a blood sample. An INR (international normalized ratio) test is a type of calculation based on the PT test results. Prothrombin is a protein made in the liver that is part of the blood clotting (coagulation) process. These clotting factors work together to form a blood clot. Keeping these factors in balance is a crucial measure of good wound healing, excessive bleeding or the formation of clots that could cause a stroke or a heart attack.

18. MRI Plaque View– This is a relatively new cardiovascular disease measurement tool. It measures the actual morphology of the plaque including multi–contrast identification of plaque compounds such as lipid core, calcification and hemorrhage potential. It also assesses carotid plaque burden such as maximum wall thickness and normalized wall index. Vulnerable plaque can be determined by thrombosis risk, lipid–rich nuclei or any plaque demonstrating fibrous cap rupture. In other words, the MRI Plaque View can see the specific risk of plaque structure (potential lesions) as well as the health of the various levels of the endothelial lining.

19. PULS Cardiac Test– The PULS Cardiac Test predicts the likelihood that a person will have a heart attack within the next five years. It works by detecting the instability of lesion ruptures. PULS stands for Protein Unstable Lesion Signature, and it measures biomarkers in the body’s immune system response. Over time these cellular damage markers identify lesions that can rupture if they become too large. The new mRNA vaccines have now been shown to dramatically increase endothelial inflammation and the risk of acute coronary syndrome (ACS). This condition can occur more rapidly with the influence of this viral related damage then might usually be the case. This type of vaccination seems to induce damage to heart cells leading to cell death and myocardial infraction (heart attack) in people with no previous history of this disease. This damage can be found and measured with the PULS Cardiac Test. This test may be more accurate that cholesterol, calcium and plaque tests, which do not have the same benefits in terms of predictive diagnosis.²⁷

Optimizing the Cellular Repair and Replacement Process

The human body is a complex biochemical structure with many systems and pathways to navigate in order to optimize cellular functions for maintaining good health. Repairing the DNA damage caused by poor nutrition, toxins, radiation, injuries and aging is one of the most complex of these systems. See the basic diagram of this process at the top of this article.

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

Who Can Benefit From This Program

There are at least four distinct groups that can benefit from the heart tissue repair program described above. There may be more categories, but these have been identified thus far.

1. Existing heart disease and stroke patients- This group is easily identified by their prior diagnosis and treatment status. Most of them will already be on medication of some kind and/or have had surgery. These patients are most likely being treated by allopathic doctors and will need to find an integrated doctor to work with in order to effectively utilize the protocol outlined in this article.

2. Existing Long COVID patients- These patients may or may not be under a doctor’s care. The ones that are could be working with an allopathic or a natural doctor of some kind. Most natural doctors will understand and know how to use this protocol. Natural doctors are also often called naturopaths or functional medicine doctors.

3. Existing chronically ill patients- Some patients may have existing conditions such as diabetes or cancer, which has implications for the risk of cardiovascular challenges. Heart failure is a major risk factor for these patients and allopathic doctors may not be aware of the diagnostic and treatment alternatives discussed in this article. A second natural doctor may need to be involved to provide a second opinion or be added to the team of health practitioners being used by a patient.

4. People interested in prevention- Some people may have a family history of heart disease or simply be interested in not being surprised by a heart attack or stroke after the age of forty. This natural protocol is definitely worthy of consideration for those interested in prevention. The following chart explains how cells deteriorate gradually in six stages of cellular decline.

This program can identify and stop this deterioration with proven physiological assessment tools.

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

The Secondary DNA Cellular Repair Nutraceuticals

1. Curcumin- It is very difficult to achieve effective cellular repair if there is inflammation in the body. Curcumin has major anti-inflammatory and anti-oxidant properties and is also known to help in the repair of damaged tissue, such as cartilage. Curcumin also boosts brain-derived neurotrophic factor, which has improved brain function in brain related illnesses such as dementia and Alzheimer’s.

2. Zinc- Zinc has strong anti-oxidant properties, but this is just one of its many important functions in the cellular repair and replacement process. Zinc picolinate can repair a damaged stomach lining in 30 days. Zinc plays an important role in the cell replication process by also helping with the production of growth hormones and assisting the DNA synthesis process. Zinc is a cofactor of antioxidant and DNA repair enzymes, and is involved in apoptosis, cell proliferation, protection against free radicals, and DNA repair pathways. Zinc supplementation in the elderly has been shown to limit DNA damage.

3. Vitamin B- All of the B vitamins are important, but in terms of cellular repair and replacement a few of the B vitamins go to the top of the list. Vitamin B6, B12 and folate are methylators, which means they are needed to help convert amino acids into hormones, neurotransmitters and other important biochemicals. Vitamin B1, in the form of benfothiamine, is able to help rebuild the myelin sheath (outer lining) of our nerves. As a co-factor in many cellular functions, vitamin B is crucial to all of the cells in key organs such as the brain, heart, liver, kidneys, blood vessels and intestines. As part of the cellular repair process it is important to consume a vitamin B complex and also take additional amounts of vitamin B1 as benfothiamine, B6. B12 and folate.

4. Molecular hydrogen- Molecular hydrogen (H2) is the smallest molecule capable of easily penetrating every cell, including cells in the brain. This is very important because H2 helps to increase oxygen delivery to our cells and ensure a balance is maintained in the release of protective cytokines to fight infections. Supplementation with H2 has been shown to improve cellular function in the nervous system, the cardiovascular system, the digestive system, the respiratory system, the urinary system, the reproductive system and the brain.

5. Nicotinamide Adenine Dinucleotide (NAD)- NAD is a molecule in the niacin (vitamin B3) family of nutrients that plays a key role in the cellular aging process. Its role is as a coenzyme, or helper molecule, in many biological processes. As our cells go through the normal cell-replacement process, there are a few checkpoints in this cycle where everything must be perfectly aligned to allow for a good new cell to be produced. NAD plays a key role in insuring that all cellular systems are working efficiently in this replacement cycle. If nutrition, sleep, stress, toxins and exercise are all at optimal levels, then having good NAD levels provides the insurance for excellent cellular replacement. This replacement process also occurs when cells have been damaged as is the case with the cells of COVID-19 patients.

6. Pycnogenol- This supplement comes from French Pine Bark and has been shown to have protective capabilities in several cellular functions including the repair of brain cells after a stroke. It has also been shown to improve kidney flow and function, as well as help to reduce blood clots as an anticoagulant. This is important for COVID-19 patients since blood clots have been found in many parts of the body even after symptoms have been resolved.

7. Probiotics- These beneficial bacteria are crucial to the development of most nutrients in the intestines. They help to control pathogens that come into the body and they break down food for the nutrients they contain. Probiotics also help to initiate the development of anti-inflammatory and immune function molecules. These beneficial microbiotas can significantly influence molecular mechanisms and pathways that can influence both the prevention and resolution of numerous chronic illnesses, as well the epigenetic expressions that can determine our future health.

8. Olive Leaf Extract- Olives are one of the cornerstones of the Mediterranean Diet and have been helping people to be healthier for thousands of years. One of the primary functions of olive leaf extract is to prevent viral infections. However, it has also been shown to improve cardiovascular health, lower blood pressure and protect organs such as the pancreas, liver and the kidneys. Olive Leaf Extract has anti-inflammatory properties and has been proven to repair tissue damage related to kidney disease, upper respiratory illnesses, fatty liver disease and heart disease.

9. Digestive enzymes- As we age our body makes fewer digestive enzymes, which are needed for the processing of food, metabolic functions and the delivery of nutrients to our cells. By the time we are fifty years old our bodies may be making up to 50% less digestive enzymes then when we were twenty years old. This is part of the body’s programmed aging process. Most raw foods have sufficient enzymes to process the nutrients in them, however cooking foods destroys all enzymes. There are over 5,000 enzymes in the body responsible for many functions including the cellular repair and replacement process, as well as helping to kill germs, bacteria, viruses and other pathogens.

10. Selenium- This mineral is a known ROS scavenger, which means it cleans up oxidative damage. It can also be incorporated in the amino acid selenomethionine, which may up-regulate a specific DNA repair pathway. Good sources are Brazil nuts, yellow fin tuna and supplements. Tuna should be eaten sparingly due to high levels of toxins.

11. Resveratrol- Resveratrol is a natural polyphenolic compound, specifically a stilbene, which is found in significant amounts in grapes, berries, peanuts, and other plant sources, as well as in red wine. This compound has become very popular due to its multiple reported properties that include inflammation-mediating, cardio-protective, antioxidant, and anti-cancer, among other things. As an anti-cancer compound, low-dose resveratrol accelerates non-mutagenic repair of DNA damage in mouse embryonic stem cells exposed to ionizing radiation. Furthermore, resveratrol was shown to significantly reduce DNA damage from arsenic compounds in non-cancerous mammalian cells by enhancing repair activities, especially if used prior to exposure. Resveratrol repairs DNA damage and activates the repair mechanisms in various cancer cell lines such as prostate cancer cells, colon cancer cells, and breast cancer cells. Indeed, head and neck squamous cell carcinoma cells as well as breast cancer cells receive more DNA damage than their normal counterparts. Resveratrol has been shown to affect different DNA repair pathways in MCF7 breast cancer cells by reducing the expression of several genes involved in this activity and where mismatch repair and homologous recombination stand-out such as most affected. Resveratrol made breast cancer cells more susceptible to cisplatin, and specifically in cisplatin-resistant MCF7 cells, resveratrol was able to re-sensitize cells by decreasing several key components of the homologous recombination pathway.

12. Quercetin- Quercetin is a flavonoid found in a variety of foods, including fruits and vegetables such as apples, berries, capers, grapes, onions, shallots, tea, and tomatoes, as well as many seeds such as nuts, flowers, bark, and leaves. Quercetin is known for its anti-inflammatory, anti-hypertensive, vasodilatory, anti-hypercholesterolemic, anti-atherosclerotic, antioxidant and, more recently, anti-cancer effects Meanwhile, in some colorectal cancer, cervical cancer and breast cancer cell lines, quercetin acted as a radiosensitizer by blocking ATM activation and its downstream signaling, thereby prolonging the persistence of damage and inducing apoptosis. Quercetin can potentiate the effects of PARP inhibitors, preventing efficient repair of DNA damage, and where inhibition of BRCA2 activity plays an important role during the passage of single-strand breaks to double-strand breaks during DNA replication. (1-12 inclusive²⁶

Nutraceutical Honor Role

The following nutraceuticals also have a very good track record in the prevention and treatment of heart and circulation challenges on factors not related specifically to tissue repair:

• D-ribose
• L-carnitine
• Grape seed extract
• Folate
• Inositol
• L-arginine
• Garlic
• Serrapeptase
• Nattokinase
• Lumbrokinase
• Hawthorn berry

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

The Primary DNA Cellular Repair Nutraceuticals

Vitamin C- The extracellular matrix (ECM) is a complex mix of proteins and polysaccharides synthesized and secreted by the cells in the extracellular space. ECM has a fibrillar structure in most tissues and provides a structural framework for the surrounding cells that is essential for tissue/organ morphogenesis, as well as for their regeneration after injury. Collagens are the most abundant proteins in the ECM and thus the most abundant proteins in the body. Vitamin C is crucial to the production of collagen and impacts ECM homeostasis by regulating collagen synthesis and maturation. Therefore, vitamin C plays a key role in the repair of heart tissue damaged by the heart attack or by a viral infection such as COVID-19.

Vitamin C is also classified as an antioxidant able to prevent damage being caused by free radicals resulting from inflammation, infection and toxins. Toxins are missing an electron in their molecular make-up while vitamin C has an extra electronic that can be used to neutralize the free radical, thus avoiding damage to cells in the epithelial lining of the arteries and capillaries.

Vitamin C is also influential as a co-factor in many enzymatic reactions in the body that determine how stem cells are differentiated into cells needed are repair and replacement in the body. While stem cell production declines with age those that are made can be used when cells are damaged due to a heart attack or a viral infection such as COVID-19. Vitamin C therefore appears to play an important role in both the production of cells in the heart and circulatory system as well as the cellular repair and replacement process.¹⁴

Vitamin D3- The role of vitamin D3 in bone health, genetic expression, virus protection and cancer prevention and treatment are well known. Less well known Is the role vitamin D3 plays in the cellular repair process, especially cells in the heart and circulation system. The genesis for this understanding came during research on the role of the endothelium of the arterial wall which revealed its behavior as an organ and not simply a lining which allowed water and electrolytes to pass throw. One of its key functions was determined to be the restoration and maintenance of nitric oxide levels. This was accomplished by vitamin D3’s ability to increase cytoprotective nitric oxide while reducing peroxynitrite a negative molecule in nitric oxide homeostasis. This favorable rebalancing allowed cells in the endothelium to be repaired more rapidly.

The logical extension of this initial finding was to determine if cells in the heart also benefited from this improvement in nitric oxide rebalancing. The study used nano-medical methods of measurement and analysis to evaluate vitamin D3’s role in the nitric oxide theory. The results were conclusive and it can now be confirmed that vitamin D3 does play a key role in the repair of heart cells damaged by myocardial infarction, better known as a heart attack. It can then be logically argued that vitamin D3 can also play a key role in the repair of heart cell damage done by a virus such as COVID-19.¹⁵

Modified Citrus Pectin- This grapefruit skin extract is modified via size reduction as well as temperature and pH adjustments producing a molecule with impressive medical properties. In the case of heart and circulation health MCP inhibits the expression of Galectin-3, a biomarker associated with fibrosis and inflammation in patients with heart failure. Using sophisticated cellular analysis tests for mRNA and protein expression levels of signaling molecules and pro-inflammatory cytokines, researchers found some important effects of consuming MCP. It was demonstrated that MCP ameliorated cardiac dysfunction, decreased myocardial injury and reduced collagen deposition.

MCP also down-regulated pathways for other pathogenesis biomarkers which impact inflammation related to myocardial fibrosis. Together the collective influence of these down-regulation pathways and biomarkers supports the use of MCP for the treatment of myocardial fibrosis after myocardial infarction (heart attack). One of the best measures of success would be the blood test for Galectin-3.¹⁶

Coenzyme Q10- This valuable nutraceutical has a proven track record for the prevention and the treatment of hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, kidney disease and Parkinson’s Disease. The primary factors related to its effectiveness on heart related illness are as follows.

• CoQ10 exhibited strong anti-inflammatory properties during various heart surgery procedures, and during recovery, as measured by C-reactive protein levels.
• CoQ10 has been shown to reduce the negative side effects of the use of statin drugs for the reduction of cholesterol in the body as well as reduce myopathic side effects.
• CoQ10 can significantly improve the treatment of patients with cardiomyopathy which usually involves some genetic or acquired dysfunctions in the left ventricular or mitral valve function. Dosage of 200 mg/day improved symptoms of fatigue and dyspnea as well as improving posterior wall thickness and mitral valve function.
• Viral myocarditis inflammation (E.g. COVID-19) is a serious factor and CoQ10 was able to suppress this inflammation both in the prevention and the treatment of this viral infection.
• CoQ10 helps to both prevent and treat heart failure by improving the heart contraction force as well as cellular oxygen levels.
• CoQ10 appears to improve the survival of myocardial cells during ischemic events, and limit post infarction myocardial remodeling. This may be at least partially due to its ability to protect the DNA of all cells from damage of any kind, including heart cells.¹⁷

Magnesium- Severe magnesium deficiency can lead to a life-threatening heart attack. Magnesium deficiency sensitizes the myocardium due to the toxic effects of various drugs, as well as to hypoxia. Therefore, magnesium supplementation may have significant cardio-protective effects. Deficiency in magnesium may also lead to chronic electrical instability of the myocardium by affecting the sodium and calcium flow into the cells. Extracellular magnesium ions have been found to exert a profound beneficial influence on the flexibility and tissue structure of the arteries, arterioles and veins from a number of regional vasculatures. Most importantly, magnesium is the transport agent that delivers glucose and oxygen to cell membranes and the mitochondria for energy production. One of the challenges for efficient delivery of magnesium into the cell is the fact that it is delivered to the inside of the membrane of the cell and not always directly to the mitochondria. If the cellular repair process is to be optimized then this energy production process should be optimized with the addition of berberine, which is the next nutrient on this list.¹⁸

Berberine- Berberine is a natural compound found in plants such as European barberry, Oregon Grape and goldenseal. Its primary benefit is in the production of energy in the cell when it uses the Glut-4 molecule to transport glucose and oxygen from the inside of the cellular membrane to the mitochondria of the cell. Other benefits include:

• Berberine exerts profound antioxidant and anti-inflammatory effects against myocardial ischemia/reperfusion injury. SIRT1 signaling clearly shows reduced oxidative damage and anti-inflammatory effects.
• Berberine possesses a variety of pharmacological and biological properties and can potentially enhance cardiovascular performance in multiple conditions including reduced myocardial apoptosis and necrosis.
• Berberine has also been shown to be a therapeutic agent for lipid lowering, including reductions in serum cholesterol and LDL-C.
• By the efficient delivery of glucose into the cells berberine also lowers the level of circulating sugar that can cause oxidative damage to the cardiovascular system, including the heart.¹⁹

Specialized Pro-resolving Mediators- The inflammatory tissue response after acute myocardial infarction determines the subsequent healing process. The various leukocytes such as neutrophils, macrophages and lymphocytes contribute to the clearance of dead cells while activating reparative pathways necessary for myocardial healing. Cardiomyocyte death triggers wall thinning, ventricular dilatation, and fibrosis that can cause left ventricular dysfunction and heart failure. The ultimate goal of cardiac repair is to regenerate functionally viable myocardium after myocardial infarction to prevent cardiac death. Specialized Pro-resolving Mediators have unique anti-inflammatory and cellular repair properties that can play a big role in this cellular repair process.

The advantage of using Specialized Pro-resolving Mediators is that they act on specific cellular receptors to regulate leukocyte trafficking. They also blunt the release of inflammatory mediators, while also promoting clearance of dead cells and tissue repair. Since SPM is a concentrated form of omega-3 fatty acids it has positive effects on controlling inflammation, including the reduction of cytokines, endothelial cell activation and platelet aggregation, heart rate and cardiac function. Inflamed cells are able to return to normal functionality as measured by the elimination of symptoms and achieving normalization of various biomarkers such a C-reactive protein and the aforementioned cytokine markers.²⁰

Astaxanthin- Astaxanthin is a red pigment in certain sea algae known for its ability to scavenge free radicals for the prevention and reversal of chronic illness. However, less well known is its ability to repair the damage to the heart and circulatory system caused by a heart attack, a COVIV-19 infection or a COVID-19 vaccination. The pathways for achieving this repair process are as follows:

• It is able to capture free radicals in the double layers of the cell membrane and remove them better than other antioxidants such as vitamin E or beta carotene.
• It also elevates antioxidant enzymes such as catalase, superoxide dismutase, peroxidase, and glutathione-S-transferase.
• It also exhibits a number of other health promoting properties such as being anti-inflammatory, anti-apoptosis, and autophagy-modulatory activities.
• Astaxanthin has also been shown to activate pharmacological and mechanistic anti-inflammatory pathways in the defense of complications related to the corona virus.
• Astaxanthin also inhibits mitochondrial dysfunction, which is crucial to cellular survival and repair.

The proven therapeutic benefits of astaxanthin has been shown in related clinical trials to be important in the treatment of metabolic syndrome, atherosclerosis, cognitive impairment, muscle damage, visual fatigue and dermatological diseases.²¹

L-taurine- This amino acid has demonstrated unique and valuable capabilities in the treatment of chronic illnesses such as heart disease, high blood pressure, diabetes and various brain disorders. In most cases amino acids are the building block proteins for cellular repair and replacement. However, in the case of taurine other cellular health improvement properties have been found and confirmed.

• Taurine influences various cellular functions due to its sulfonic acid makeup such as osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids.
• Taurine has shown anti-inflammation effects including blood pressure regulation and protection against cardiovascular disease.
• Taurine displays cardio-protective abilities following cardiac injury. Following a coronary artery occlusion-induced ischemia the consumption of taurine resulted in significantly smaller myocardial infarct size, elevated levels of superoxide dismutase, and decreased levels of interleukin and tumor necrosis factor alpha.
• In patients with heart failure, due to coronary heart disease, taurine consumption improved tolerance and recovery during increased exercise.
• In one study continued supplementation with taurine increased taurine to optimal levels which corrected cardiomyopathy by restoring mitochondrial function and improving cardiac energy metabolism.

These results point clearly to the ability of L-taurine to influence various cellular repair pathways leading to the maintenance of intracellular homeostasis.²²

Vitamin E- Vitamin E is particularly effective in protecting cell membranes due to its strong anti-oxidant properties. It has a proven track record in the treatment of heart disease, vascular disease and fatty liver disease. By repairing damaged cell membranes vitamin E ensures that cellular repair inside the cells can be done effectively since the membrane regulates both the intake of nutrients and the removal of waste from every cell in the body. Vitamin E is also a Reactive Oxygen Species (ROS) scavenger, specifically targeting lipid oxidation and can prevent oxidized fats from damaging DNA. Vitamin E also helps to extend the antioxidant neutralizing powers of vitamin C making these nutrients a powerful one-two punch of preventing and treatment cardiovascular disease. It also appears to have the positive effect of limiting DNA damage. Vitamin E is actually eight different compounds, four as tocopherols (more common in supplements) and four as tocotrienols. The latter are the ones that manage inflammation better than the tocopherols. Therefore, supplements with both tocopherols and tocotrienols should be preferred in the repair of damaged cardiovascular cells.²³

Arterosil- The primary ingredient in this natural medicine product it rhamnan sulfate which is a sulfated polysaccharide extracted from two types of a sea algae with the biochemical names Monostroma Latissium and Monostroma Nitidum. This compound has now been shown to provide protection for the endothelial glycocalyx, which plays an essential role in the endothelium of all arteries, veins and capillaries in our body. The endothelium is involved in the control of vascular barrier function, blood clotting, inflammation, oxidative stress, endothelial nitric oxide production, and the growth of new blood vessels. The glycocalyx is the first line of defense for this endothelium lining by regulating the access of circulating LDK cholesterol and leukocyte to the vessel wall, which is the key step in the development of atherosclerotic plaques. The following clinical benefits of Arterosil have been observed.²⁴

• Arterial health: A study conducted at Baylor University looked at its effects on arterial elasticity, which is a measure of endothelial health. Within hours of taking Arterosil, arterial elasticity increased by an average of 89.6%.
• Blood pressure: In a three-month study, this nutraceutical markedly lowered diastolic blood pressure, with significant improvements beginning within the first month.
• Microcirculation: In another 3-months study conducted at Hypertension Institute, 20 subjects with lower extremity neuropathy showed significant improvement in microcirculation related to nitric oxide production, vasodilation, small nerve fiber function, and also in neuropathy symptoms.
• Plaque regression: Most remarkable, Arterosil has been shown to actually reverse cardiovascular disease. MRIs of men and women with significant carotid artery plaque who took Arterosil for two months showed an average plaque regression of 46.8% in men and 64% in women.
• Plaque stability: This same study also examined the makeup of the carotid plaques. Most heart attacks and strokes are caused by “vulnerable plaques”: unstable, lipid-filled lesions that are prone to rupture. The plaque regression noted above included not only a significant decrease in overall size of plaque built up, but also a 56% average reduction of the lipid core.

This makes Arterosil one of the most powerful of the nutraceuticals mentioned in the preceding list. There are other useful heart health nutrients, but these ten have the best scientific evidence, and have shown the best clinical results in the treatment of damaged heart and circulation cells. This includes damage done by heart attacks, COVID-19 infections or by COVID-19 injections.

Omega-3 Fatty Acids- Omega-3 fatty acids are a primary anti-inflammatory nutrient with many proven benefits for the prevention and treatment of chronic illness. One of main benefits is the ability of Omega-3 fatty acids to soften cell membranes, which helps to improve the entry of nutrients and the removal of waste from the cells. Clinical studies have shown benefits to the following chronic illnesses.

• Cardiovascular disease
• Cancer of the breast, colon and prostate.
• Cognitive function including depression, ADHD, dementia and Alzheimer’s.
• Inflammatory bowel disease
• Childhood allergies
• Cystic fibrosis
• Arthritis
• Macular degeneration

There are some cautions with the use of Omega-3 fatty acids including its impact on blood thinning medications. However, for the most part it is safe when used at appropriate dosages.²⁵

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

Abstract

Cardiovascular disease is the number one cause of death in North America. It’s also a greater risk these days because many people are suffering heart issues as a result of COVID-19 infection, as well as the vaccinations. Conventional medical has traditionally treated heart disease, such as a heart attack, stroke or a diagnosis of arteriosclerosis with medications or surgery. The COVID-19 virus has expanded the usual causal factors of this illness, like poor diet, smoking and lack of exercise, to include cellular damage caused by the coronavirus’ invasion of cells via the ACE-2 receptors. These receptors are found in high numbers on highly active cells like those present in the heart and the circulatory system. Conventional treatments have been somewhat successful in managing these conditions, but new scientific evidence is pointing to the capability of damaged cells in the cardiovascular system to be repaired, potentially leading to better and longer survival outcomes. New diagnostic tools are able to find cellular damage five to ten years before cardiovascular events occurs. Advance dietary approaches and nutraceuticals have also shown promise in the repair of cellular damage both from traditional causes, as well as from damage related to COVID-19 infections and injections. This presents an ideal opportunity for doctors, scientists and those responsible for healthcare decision-making to encourage the use of this new prevention and treatment protocol. Implementing this strategy should include well-designed, long-term studies that validate the proof of concept outlined in this article.

Every year over 800,000 people in the United States have a heart attack and over 90% of them survive, at least initially.¹ The causes are very well known but are worth repeating.

• Eating an unhealthy diet
• Being overweight or obese
• Excessive alcohol use
• Having diabetes (many people are unaware they are prediabetic or diabetic)
• Having high blood pressure (many people are unaware they have high blood pressure)
• Being chronically stressed
• Not getting enough physical activity
• Low levels of magnesium (as measured by the RBC magnesium test)
• High ratio of LDL to HDL cholesterol (is a contributing factor, but not a direct cause)
• Consuming tobacco in any way

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine

Next Page: Standard of Care vs Optimized Care

Understanding the cellular repair process

Every cell in the body is designed to repair itself after some damage has occurred. The process is designed to occur in a timely manner, approximately two to three weeks in most cases. However, this repair requires specific programmed actions to take place within each cell. If these do not happen for some reasons then the repairs may not produce a completely healthy cell to be produced. In fact, if all of the conditions are not followed according to design the cells can adopt an alternative strategy that provides a less than perfect repair, but is usually a satisfactory repair to allow each cell to continue to function at an acceptable level of functionality.

DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, environmental chemicals and radiation that damage their DNA, thus corrupting genetic information. In addition, normal cellular pH and temperature create conditions that are hostile to the integrity of DNA and its nucleotide components. DNA damage can also arise as a consequence of spontaneous errors during DNA replication.

The DNA repair machinery continuously scans the genome and maintains genome integrity by removing or mending any detected damage. Depending on the type of DNA damage and the cell cycle status, the DNA repair machinery utilizes several different pathways to restore the genome to its original state.

When the damage and circumstances are such that the DNA cannot be repaired with absolute fidelity, the DNA repair machinery attempts to minimize the harm and patch the insulted genome well enough to ensure cell viability. Accumulation of DNA alterations that are the result of cumulative DNA damage and utilization of “last resort” low fidelity DNA repair mechanisms is associated with cellular senescence, aging, and cancer.

The cell replacement process

There are specific “checkpoints” in the cellular repair process when the quality of each cell’s replacement is checked and verified. If the quality criteria are not being met the cell can slow down the replacement process in order to find the missing ingredients.

1. G1 and G2 are known as Gap phases when the cell is actively metabolizing but not dividing.
2. S is the synthesis phase when the chromosomes duplicate as a result of DNA replication.
3. M is the mitosis phase when the chromosomes separate in the nucleus and the division of the cytoplasm occurs.

There are two checkpoints in this cycle at the end of G1 and G2 that prevent the cell from entering synthesis or mitosis before they are ready to do so. If this cycle is disrupted in any way the cell becomes vulnerable to faulty replication, which can become the beginning of the development of cancer. This disruption can occur to many factors that were previously mentioned including:

• The lack of adequate nutrition including enzymes, hormones, vitamins, etc.
• The lack of adequate removal of waste or toxins from the cell
• The presence of emotional stress
• The exposure to cell disruptors such as radiation or chemotherapy
• Inherited genetic pre-dispositions
• There are seven main pathways employed in human DNA repair: DNA damage bypass, DNA damage reversal, base excision repair, nucleotide excision repair, mismatch repair, repair of double strand breaks and repair of interstrand cross-links (Fanconi anemia pathway). DNA repair pathways are intimately associated with other cellular processes such as DNA replication, DNA recombination, cell cycle checkpoint arrest and apoptosis
• Double strand breaks DSBs can be directly generated by some DNA damaging agents, such as X-rays, radiation, viruses or spike proteins and reactive oxygen species (ROS), caused by chemical toxins in the air, water or food.
• We have just seen that cells contain multiple enzyme systems that can recognize DNA damage and promote the repair of these lesions. Because of the importance of maintaining intact, undamaged DNA from generation to generation, cells have an additional mechanism that helps them respond to DNA damage: they delay progression of the cell cycle until DNA repair is complete. For example, one of the genes expressed in response to the E. coli SOS signal is sulA, which encodes an inhibitor of cell division. Thus, when the SOS functions are turned on in response to DNA damage, a block to cell division extends the time for repair. When DNA repair is complete, the expression of the SOS genes is repressed, the cell cycle resumes, and the undamaged DNA is segregated to the daughter cells.
• This same delay in the repair process is what allows heart attack patients and COVID-19 myocarditis patients to repair the cellular damage if they are able to create an ideal repair and recovery environment within the body.
• Damaged DNA also generates signals that block cell-cycle progression in eucaryotes. The orderly progression of the cell cycle is maintained through the use of checkpoints that ensure the completion of one step before the next step can begin. At several of these cell-cycle checkpoints, the cycle stops if damaged DNA is detected. Thus, in yeast, the presence of DNA damage can block entry into the G1 phase; it can slow DNA replication once begun; and it can block the transition from S phase to M phase. The DNA damage results in an increased synthesis of some DNA repair enzymes, and the delays further facilitate repair by providing the time needed for repair to reach completion.
• The importance of the special signaling mechanisms that respond to DNA damage is indicated by the phenotype of humans who are born with defects in the gene that encodes the ATM protein, a large protein kinase. These individuals have the disease ataxia–telangiectasia (AT), whose symptoms include neurodegeneration, a predisposition to cancer, and genome instability. In both humans and yeasts, the ATM protein is needed to generate the initial intracellular signals that produce a response to oxygen-inflicted DNA damage, and individual organisms with defects in this protein are hypersensitive to agents that cause such damage, such as ionizing radiation.
• The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states:

1. an irreversible state of dormancy, known as senescence
2. cell suicide, also known as apoptosis or programmed cell death
3. unregulated cell division, which can lead to the formation of a tumor that is cancerous

The DNA repair ability of a cell is vital to the integrity of its genome and thus to the normal functionality of that organism. Many genes that were initially shown to influence life span have turned out to be involved in DNA damage repair and protection¹³.

Disclaimer: While this protocol is supported by solid scientific evidence it is always advisable to consult a well-trained and qualified medical professional to ensure that individual biochemistry and conditions are taken into consideration.

Repairing DNA Damaged Cardiovascular Cells with Natural Medicine