1. Centers for Disease Control and Prevention: Interactive Atlas of Heart Disease and Stroke. Accessed on November 24, 2021
  2. Amini, M., Zayeri, F. & Salehi, M. Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017. BMC Public Health 21, 401 (2021).
  3. A. C. Razavi, et al.. Early contributors to healthy arterial aging versus premature atherosclerosis in young adults: The Bogalusa Heart Study. Journal of the American Heart Association. October 5, 2021.
  4. J. Fuhrman. Do angioplasty and stents improve survival? Studies expose limitations of the popular heart procedure. Very Well Health. Updated on December 4, 2019 and medically reviewed by Richard Fogoros, M.D.
  5. Centers for Disease Control and Prevention. Underlying Cause of Death, 1999-2019. CDC WONDER Online Database. Atlanta, GA: 2018.
  6. S. S. Virani, A. Alonso, H. J. Aparicio, E. J. Benjamin, M. S. Bittencourt, C.W. Callaway, et al. Heart disease and stroke statistics – 2021 update: A report from the American Heart Association. Circulation. 0221;143:e254-e743.
  7. C. D. Fryar, T-C Chen, X. Li. Prevalence of uncontrolled risk factors for cardiovascular disease: United States, 1999-2010 [PDF-494K]. NCHS data brief, no.103. Hyattsville, MD: National Center for Health Statistics: 2012.
  8. T. Thum, SARS-CoV-2 receptor ACE2 expression in the human heart: Cause of the post-pandemic wave of heart failure? European Heart Journal. 2020 May 14;41(19):1807-1809. Published online 2020 May 8.
  9. C. Bens. Special Report: An emerging health crisis exposed by the COVID pandemic, TotalHealth. March 2021.
  10. Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning Circulation. 2021;144:A10712 8 Nov 2021
  11. Baylor College of Medicine. “Why the heart does not repair itself: New insights.” ScienceDaily, 5 June 2017.
  12. J. Salazar. Is the COVID-19 Vaccine linked to heart problems like myocarditis and pericarditis in young people? Connecticut Children’s Medical Center. June 7, 2021: updated June 16, 2021.
  13. National Center for Biotechnology Information. PubChem Pathway Summary for Pathway R-HSA-73894, DNA Repair, Source: Reactome. Accessed Mar. 1, 2022.
  14. C. D’Aniello, F. Cermola, E. J. Patriarca and G. Minchiotti, Vitamin C in stem cell biology: Impact on extracellular matrix homeostasis and epigenetics. Environmental Stimulus on Stem Cell Behaviour. 20 April 2017.
  15. A. Khan, H. Dawoud, T. Maliniski. Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1, 25-dihydroxy vitamin D3 – clinical implications for cardiovascular disease. International Journal of Nanomedicine. 19 January 2018, Volume 2018:13; 455-466
  16. G.-R. Xu, C. Zhang, H.-X. Yang, J.-H. Sun et al. Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-kB signaling pathway. Biomedicine & Pharmacotherapy, 126:June 2020.
  17. V. Zozina, S. Covantev, O. Goroshko, L. Krasnykh, & V. Kukes, Coenzyme Q10 in cardiovascular and metabolic diseases: Current state of the problem. Current Cardiology Reviews, 14:3, 2018.
  18. J. DiNicolantonio, J. Liu, & J. O’Keefe, Magnesium for the prevention and treatment of cardiovascular disease. Statistics from
  19. L Yu, Q. Li, B. Yu, Y. Yang et al. Berberine attenuates myocardial ischemia/reperfusion injury by reducing oxidative stress and inflammation response: Role of silent information regulator 1. Oxidative Medicine and Cellular Longevity. 2016: 1689602.
  20. G. Leoni & O. Soehnlein, (Re) Solving repair after myocardial infarction. Front Pharmacology; 66 November 2018.
  21. R. Fassett & J. Coombes. Astaxanthin in cardiovascular health and disease. Molecules. 2012 Feb;17(2):2030-2048.
  22. T. Qaradakhi, L. Gadanec, K. McSweeney, J. Abraham, V. Apostolopoulos & A. Zulli, The Anti-inflammatory effect of taurine on cardiovascular disease. Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia, Nutrients 2020:12(9), 2847.
  23. M. Ash. The next generation vitamin E: How tocotrienols prevent and repair heart, brain and liver disease. Clinical Education. Thursday, 16 May 2013.
  24. T. Okamoto, N. Akita, M. Terasawa, T. Hayashi, & K. Suzuki. Rhamnan sulfate extracted from Monostoma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells. Journal of Natural Medicines. 73, 614-619(2019).
  25. Sakai C, Ishida M, Ohba H, Yamashita H, Uchida H, et al. (2017) Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells. PLOS ONE 12(11): e0187934.
  26. Lagunas-Rangel FA and Bermúdez-Cruz RM (2020) Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells.
  27. Steven R Gundry, mRNA COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning’ , Circulation 8 November 2021,
  28. Raghavan S, Kenchappa DB and Leo MD (2021) SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity. Front. Cardiovasc. Med. 8:687783. doi: 10.3389/fcvm.2021.687783.
  29. Hardell, L., Carlberg, M.”[Comment] Health risks from radiofrequency radiation, including 5G, should be assessed by experts with no conflicts of interest“. Oncology Letters 20.4 (2020):
  30. Luiking YC, Engelen MP, Deutz NE. Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care. 2010;13(1):97-104. doi:10.1097/MCO.0b013e328332f99d.
  31. Steven R Gundry, mRNA COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning’ , Circulation 8 November 2021, `#
  32. Cincinnati Children’s Hospital Medical Center. “Biology of mending a broken heart: Scientists test way to stop heart damage after cardiac injury.ScienceDaily, 28 September 2017.
  33. Kamierczak-Baraska, Julia et al. “Nutrition Can Help DNA Repair in the Case of Aging.Nutrients vol. 12,11 3364. 1 Nov. 2020, doi:10.3390/nu12113364.
  34. Rizzo C, Carbonara R, Ruggieri R, Passantino A and Scrutinio D (2021) Iron Deficiency: A New Target for Patients with Heart Failure. Front. Cardiovasc. Med. 8:709872. doi: 10.3389/fcvm.2021.709872
  35. Kalayoglu MV, Libby P, Byrne GI. Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA. 2002 Dec 4;288(21):2724-31. doi: 10.1001/jama.288.21.2724. PMID: 12460096.
  36. 3Chan, T.H., “Preventing Heart Disease”. School of Public Health, Harvard, January 2022,
  37. Alves QL, Camargo SB, Silva DF (2019) Role of Nutraceuticals in the Prevention and Treatment of Hypertension and Cardiovascular Diseases. J Hypertens Manag 5:037.
  38. Cummings JL, Morstorf T, Zhong K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther. 2014 Jul 3;6(4):37. doi: 10.1186/alzrt269. PMID: 25024750; PMCID: PMC4095696.
  39. Gustafson C. Dale E. Bredesen, md: Reversing Cognitive Decline. Integr Med (Encinitas). 2015;14(5):26-29.
  40. Mollace V, Rosano GMC, Anker SD, Coats AJS, Seferovic P, Mollace R, Tavernese A, Gliozzi M, Musolino V, Carresi C, Maiuolo J, Macrì R, Bosco F, Chiocchi M, Romeo F, Metra M, Volterrani M. Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review. Nutrients 2021 Jan 17;13(1):257.

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